Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd47provided by MGI
Official Full Name: CD47 antigen (Rh-related antigen, integrin-associated signal transducer)provided by MGI
Primary source: MGI:MGI:96617
See related: Ensembl:ENSMUSG00000055447 AllianceGenome:MGI:96617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IAP; Itgp; 9130415E20Rik; B430305P08Rik
Summary: Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion and thrombospondin receptor activity. Involved in positive regulation of activation-induced cell death of T cells; regulation of nitric oxide biosynthetic process; and regulation of synapse pruning. Acts upstream of or within several processes, including monocyte aggregation; opsonization; and positive regulation of phagocytosis. Located in extracellular exosome and plasma membrane. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD47 (CD47 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 39.9), liver E14.5 (RPKM 35.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 31.23 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (49671691..49732799)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (49851328..49912503)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction following Intraportal Transplantation.
Title: Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction following Intraportal Transplantation.
Expression of a mutant CD47 protects against phagocytosis without inducing cell death or inhibiting angiogenesis.
Title: Expression of a mutant CD47 protects against phagocytosis without inducing cell death or inhibiting angiogenesis.
Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases.
Title: Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases.
AMPK-mediated CD47 H3K4 methylation promotes phagocytosis evasion of glioma stem cells post-radiotherapy.
Title: AMPK-mediated CD47 H3K4 methylation promotes phagocytosis evasion of glioma stem cells post-radiotherapy.
alpha5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape.
Title: α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape.
CD47 and PD-L1 overexpression in proliferating human hepatocytes attenuated immune responses and ameliorated acute liver injury in mice.
Title: CD47 and PD-L1 overexpression in proliferating human hepatocytes attenuated immune responses and ameliorated acute liver injury in mice.
CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity.
Title: CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity.
Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis.
Title: Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis.
A metabolic role for CD47 in pancreatic beta cell insulin secretion and islet transplant outcomes.
Title: A metabolic role for CD47 in pancreatic β cell insulin secretion and islet transplant outcomes.
Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages.
Title: Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (157)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (16) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgp (e-PCR), detects polymorphism
- UniSTS:143633

AW108519 (e-PCR)
- UniSTS:180910

AI848868 (e-PCR)
- UniSTS:180911

RH124639 (e-PCR)
- UniSTS:161461

Z25524 (e-PCR)
- UniSTS:125922

AB012693 (e-PCR)
- UniSTS:163575

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding involved in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
enables thrombospondin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thrombospondin receptor activity	IEA Inferred from Electronic Annotation more info
enables thrombospondin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP export	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-12	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within opsonization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activation-induced cell death of T cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse pruning	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse pruning	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular exosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: leukocyte surface antigen CD47

Names: Rh-related antigen; integrin-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368415.1 → NP_001355344.1 leukocyte surface antigen CD47 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC107830, AK151922, BP757719

UniProtKB/Swiss-Prot

Q61735, Q921Z2

UniProtKB/TrEMBL

E5Q371, Q3U967

Related

ENSMUSP00000155684.2, ENSMUST00000230836.2

Conserved Domains (2) summary

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
NM_001368416.1 → NP_001355345.1 leukocyte surface antigen CD47 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC107830, AC158166

Consensus CDS

CCDS88938.1

UniProtKB/TrEMBL

A0A2R8W6P0, E5Q371

Related

ENSMUSP00000155178.2, ENSMUST00000230641.2

Conserved Domains (2) summary

pfam04549
Location:163 → 311

CD47; CD47 transmembrane region

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
NM_001368417.1 → NP_001355346.1 leukocyte surface antigen CD47 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC107830, AC158166

UniProtKB/TrEMBL

E5Q371

Related

ENSMUSP00000155856.2, ENSMUST00000229101.2

Conserved Domains (2) summary

pfam04549
Location:163 → 311

CD47; CD47 transmembrane region

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
NM_001368418.1 → NP_001355347.1 leukocyte surface antigen CD47 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC107830, AC158166

Consensus CDS

CCDS88939.1

UniProtKB/TrEMBL

A0A2R8VK70, E5Q371

Related

ENSMUSP00000155289.2, ENSMUST00000229206.2

Conserved Domains (2) summary

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
NM_010581.3 → NP_034711.1 leukocyte surface antigen CD47 isoform 4 precursor

See identical proteins and their annotated locations for NP_034711.1

Status: VALIDATED

Source sequence(s)

Z25524

Consensus CDS

CCDS28212.1

UniProtKB/TrEMBL

E5Q371

Related

ENSMUSP00000099853.5, ENSMUST00000084838.14

Conserved Domains (2) summary

pfam04549
Location:163 → 311

CD47; CD47 transmembrane region

pfam08204
Location:20 → 128

V-set_CD47; CD47 immunoglobulin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

49671691..49732799

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521809.5 → XP_006521872.1 leukocyte surface antigen CD47 isoform X1

UniProtKB/TrEMBL

E5Q371

Conserved Domains (2) summary

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47

pfam04549
Location:163 → 311

CD47; CD47 transmembrane region
XM_006521810.5 → XP_006521873.1 leukocyte surface antigen CD47 isoform X2

UniProtKB/TrEMBL

E5Q371

Conserved Domains (2) summary

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47

pfam04549
Location:163 → 311

CD47; CD47 transmembrane region
XM_030248985.2 → XP_030104845.1 leukocyte surface antigen CD47 isoform X4

UniProtKB/TrEMBL

E5Q371

Conserved Domains (2) summary

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region
XM_030248984.2 → XP_030104844.1 leukocyte surface antigen CD47 isoform X3

UniProtKB/TrEMBL

E5Q371

Related

ENSMUSP00000154914.2, ENSMUST00000230281.2

Conserved Domains (2) summary

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region
XM_030248986.2 → XP_030104846.1 leukocyte surface antigen CD47 isoform X5

UniProtKB/TrEMBL

E5Q371

Conserved Domains (2) summary

cd16090
Location:26 → 131

IgV_CD47; Immunoglobulin variable domain (IgV) in CD47

pfam04549
Location:142 → 290

CD47; CD47 transmembrane region