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    Tbc1d9 TBC1 domain family member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbc1d9provided by RGD
    Official Full Name
    TBC1 domain family member 9provided by RGD
    Primary source
    RGD:1308221
    See related
    EnsemblRapid:ENSRNOG00000003496 AllianceGenome:RGD:1308221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308221
    Summary
    Predicted to enable GTPase activator activity. Orthologous to human TBC1D9 (TBC1 domain family member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 123.5), Spleen (RPKM 46.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d9 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41746732..41855924, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24842166..24951383, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24328381..24429908)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ELMO domain containing 2 Neighboring gene uncoupling protein 1 Neighboring gene uncharacterized LOC134483334 Neighboring gene uncharacterized LOC108348918 Neighboring gene uncharacterized LOC102554553 Neighboring gene ring finger protein 150 Neighboring gene uncharacterized LOC134483336

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 9
    Names
    TBC1 domain family, member 9 (with GRAM domain)
    vascular Rab-GAP/TBC-containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415072.1 → NP_001402001.1  TBC1 domain family member 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZNC8, A6IYF7, D3ZXE3
      Related
      ENSRNOP00000063198.2, ENSRNOT00000065558.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41746732..41855924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097678.2 → XP_038953606.1  TBC1 domain family member 9 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9K0
      Related
      ENSRNOP00000079826.2, ENSRNOT00000113408.2
      Conserved Domains (5) summary
      smart00164
      Location:504 → 714
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:298 → 393
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cd13351
      Location:151 → 249
      PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
      cl08302
      Location:885 → 915
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl17169
      Location:938 → 1002
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_039097679.2 → XP_038953607.2  TBC1 domain family member 9 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K9K0
      Related
      ENSRNOP00000103191.1, ENSRNOT00000130407.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134539.2: Suppressed sequence

      Description
      NM_001134539.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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