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    Klhl36 kelch-like family member 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl36provided by RGD
    Official Full Name
    kelch-like family member 36provided by RGD
    Primary source
    RGD:1561366
    See related
    EnsemblRapid:ENSRNOG00000016422 AllianceGenome:RGD:1561366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in protein ubiquitination. Orthologous to human KLHL36 (kelch like family member 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 34.6), Kidney (RPKM 29.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl36 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64830218..64851251)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47921590..47942627)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52515022..52536055)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098610 Neighboring gene 40S ribosomal protein S25-like Neighboring gene ubiquitin specific peptidase 10 Neighboring gene cysteine-rich secretory protein LCCL domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa M, et al. Nat Cell Biol, 2003 Nov. PMID 14528312
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 36
    Names
    kelch-like 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017511.1 → NP_001017511.1  kelch-like protein 36

      See identical proteins and their annotated locations for NP_001017511.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081914
      UniProtKB/Swiss-Prot
      Q66HD2
      UniProtKB/TrEMBL
      A6IZL0
      Conserved Domains (6) summary
      smart00612
      Location:545 → 591
      Kelch; Kelch domain
      smart00875
      Location:147 → 247
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:58 → 583
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 381
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:35 → 138
      BTB; BTB/POZ domain
      pfam01344
      Location:332 → 382
      Kelch_1; Kelch motif

    2. NM_001434597.1 → NP_001421526.1  kelch-like protein 36

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q66HD2
      UniProtKB/TrEMBL
      A6IZL0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      64830218..64851251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255718.4 → XP_006255780.1  kelch-like protein 36 isoform X2

      Related
      ENSRNOP00000022091.2, ENSRNOT00000022091.6
      Conserved Domains (6) summary
      smart00612
      Location:545 → 591
      Kelch; Kelch domain
      smart00875
      Location:147 → 247
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:58 → 583
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 381
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:35 → 138
      BTB; BTB/POZ domain
      pfam01344
      Location:332 → 382
      Kelch_1; Kelch motif

    2. XM_039097936.2 → XP_038953864.1  kelch-like protein 36 isoform X3

      Conserved Domains (4) summary
      smart00612
      Location:335 → 363
      Kelch; Kelch domain
      cl38908
      Location:40 → 174
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam13854
      Location:350 → 389
      Kelch_5; Kelch motif
      cl28903
      Location:162 → 260
      BACK; BACK (BTB and C-terminal Kelch) domain

    3. XM_039097935.2 → XP_038953863.1  kelch-like protein 36 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R0D4
      Related
      ENSRNOP00000068927.2, ENSRNOT00000081019.3
      Conserved Domains (4) summary
      PHA03098
      Location:78 → 603
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:353 → 401
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:40 → 174
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:162 → 260
      BACK; BACK (BTB and C-terminal Kelch) domain

    RNA

    1. XR_010060018.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HD2.1 GenPept UniProtKB/Swiss-Prot:Q66HD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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