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    Bmp2k BMP-2 inducible kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bmp2kprovided by RGD
    Official Full Name
    BMP-2 inducible kinaseprovided by RGD
    Primary source
    RGD:1564828
    See related
    EnsemblRapid:ENSRNOG00000002040 AllianceGenome:RGD:1564828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatase regulator activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within regulation of bone mineralization. Predicted to be located in nuclear speck. Orthologous to human BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 349.6), Thymus (RPKM 183.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bmp2k in Genome Data Viewer
    Location:
    14p22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (12785169..12882676, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (12481194..12579411, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14126086..14226823, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 like 5 Neighboring gene U6 spliceosomal RNA Neighboring gene progestin and adipoQ receptor family member 3 Neighboring gene uncharacterized LOC134481718 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC108352846 Neighboring gene uncharacterized LOC120096572

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. Kearns AE, et al. J Biol Chem, 2001 Nov 9. PMID 11500515
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BMP-2-inducible protein kinase
    NP_001406727.1
    XP_038948586.1
    XP_038948588.1
    XP_038948589.1
    XP_063129527.1
    XP_063129529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419798.1 → NP_001406727.1  BMP-2-inducible protein kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      F1M7M4
      Related
      ENSRNOP00000082412.2, ENSRNOT00000117991.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      12785169..12882676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092658.2 → XP_038948586.1  BMP-2-inducible protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GK59, F1M7M4
      Related
      ENSRNOP00000092406.1, ENSRNOT00000101160.2
      Conserved Domains (2) summary
      cd14037
      Location:44 → 317
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:856 → 1122
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    2. XM_063273457.1 → XP_063129527.1  BMP-2-inducible protein kinase isoform X3

      UniProtKB/TrEMBL
      F1M7M4

    3. XM_039092660.2 → XP_038948588.1  BMP-2-inducible protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTX4, F1M7M4
      Related
      ENSRNOP00000057591.5, ENSRNOT00000060868.7
      Conserved Domains (2) summary
      cd14037
      Location:44 → 317
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:819 → 1085
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    4. XM_039092661.2 → XP_038948589.1  BMP-2-inducible protein kinase isoform X4

      UniProtKB/TrEMBL
      F1M7M4
      Conserved Domains (2) summary
      pfam15282
      Location:626 → 892
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
      cl21453
      Location:1 → 87
      PKc_like; Protein Kinases, catalytic domain

    5. XM_063273459.1 → XP_063129529.1  BMP-2-inducible protein kinase isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials