Strn4 striatin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Strn4provided by RGD
Official Full Name: striatin 4provided by RGD
Primary source: RGD:1307030
See related: EnsemblRapid:ENSRNOG00000016145 AllianceGenome:RGD:1307030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein domain specific binding activity. Involved in regulation of modification of postsynaptic structure. Located in dendritic spine. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Orthologous to human STRN4 (striatin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 195.0), Heart (RPKM 132.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86614193..86639959)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77482267..77511862)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78739930..78765696)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STRN4 is preferentially expressed in mushroom spines, and STRN4 specifically maintains mushroom spines but not thin spines and filopodia through interaction with the phosphatase PP2A
Title: Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI273879 (e-PCR)
- UniSTS:248837

D1Rat259 (e-PCR), detects polymorphism
- UniSTS:227080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: striatin-4

Names: striatin, calmodulin binding protein 4; zinedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107480.2 → NP_001100950.2 striatin-4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BQ198897, JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AK86, F1M6V8

Related

ENSRNOP00000095692.2, ENSRNOT00000103486.2

Conserved Domains (4) summary

COG2319
Location:422 → 752

WD40; WD40 repeat [General function prediction only]

cd00200
Location:436 → 758

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:63 → 188

Striatin; Striatin family

sd00039
Location:449 → 495

7WD40; WD40 repeat [structural motif]
NM_001161809.1 → NP_001155281.1 striatin-4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal 7-aa segment, compared to isoform 1.

Source sequence(s)

BC168948, BF408712, BQ198897, JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AK86

Related

ENSRNOP00000070127.1, ENSRNOT00000089715.3

Conserved Domains (4) summary

COG2319
Location:415 → 745

WD40; WD40 repeat [General function prediction only]

cd00200
Location:429 → 751

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:63 → 188

Striatin; Striatin family

sd00039
Location:442 → 488

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

86614193..86639959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111193.2 → XP_038967121.1 striatin-4 isoform X2

Conserved Domains (1) summary

pfam08232
Location:64 → 188

Striatin; Striatin family
XM_063261295.1 → XP_063117365.1 striatin-4 isoform X1

UniProtKB/TrEMBL

A0A8I6AK86, F1M6V8