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    Chrdl2 chordin-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chrdl2provided by RGD
    Official Full Name
    chordin-like 2provided by RGD
    Primary source
    RGD:1306179
    See related
    EnsemblRapid:ENSRNOG00000018394 AllianceGenome:RGD:1306179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable BMP binding activity. Predicted to be involved in cell differentiation and negative regulation of BMP signaling pathway. Predicted to act upstream of or within chondrocyte differentiation. Predicted to be located in extracellular region. Orthologous to human CHRDL2 (chordin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 14.3), Muscle (RPKM 7.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chrdl2 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (163755316..163782758)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154343201..154370651)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165008997..165036431)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 169 Neighboring gene small nucleolar RNA SNORA20 Neighboring gene Set nuclear proto-oncogene, pseudogene 4 Neighboring gene ribosomal protein L23,pseudogene 3 Neighboring gene DNA polymerase delta 3, accessory subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Nakayama N, et al. Development, 2004 Jan. PMID 14660436
    2. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chordin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107537.1 → NP_001101007.1  chordin-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001101007.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A0A8I6AAN2, A6I6L1, F1LW58
      Related
      ENSRNOP00000024803.7, ENSRNOT00000024803.9
      Conserved Domains (2) summary
      pfam00093
      Location:251 → 313
      VWC; von Willebrand factor type C domain
      cl17735
      Location:33 → 95
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      163755316..163782758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113275.2 → XP_038969203.1  chordin-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A6I6L3
      Conserved Domains (2) summary
      pfam00093
      Location:166 → 228
      VWC; von Willebrand factor type C domain
      cl17735
      Location:26 → 89
      VWC; von Willebrand factor type C domain

    2. XM_039113276.2 → XP_038969204.1  chordin-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A6I6L3
      Conserved Domains (2) summary
      pfam00093
      Location:166 → 228
      VWC; von Willebrand factor type C domain
      cl17735
      Location:26 → 89
      VWC; von Willebrand factor type C domain

    3. XM_017589185.3 → XP_017444674.2  chordin-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAN2
      Conserved Domains (1) summary
      cl17735
      Location:198 → 260
      VWC; von Willebrand factor type C domain
    Nucleotide Protein Strain
    Heading Accession and Version

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