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    Cep164 centrosomal protein 164 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep164provided by RGD
    Official Full Name
    centrosomal protein 164provided by RGD
    Primary source
    RGD:1561243
    See related
    EnsemblRapid:ENSRNOG00000029826 AllianceGenome:RGD:1561243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560988; RGD1561243
    Summary
    Predicted to be involved in cilium assembly. Predicted to be located in 9+2 motile cilium; apical part of cell; and nucleoplasm. Predicted to be part of ciliary transition fiber. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and nephronophthisis 15. Orthologous to human CEP164 (centrosomal protein 164). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 94.4), Adrenal (RPKM 52.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep164 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54967621..55031264, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46070901..46134511, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50069282..50132477, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 2 Neighboring gene DS cell adhesion molecule-like 1 Neighboring gene beta-secretase 1 Neighboring gene ring finger protein 214 Neighboring gene proprotein convertase subtilisin/kexin type 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cep164, a novel centriole appendage protein required for primary cilium formation. Graser S, et al. J Cell Biol, 2007 Oct 22. PMID 17954613, Free PMC Article
    2. Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish. Zhang Q, et al. Mol Biol Cell, 2012 Aug. PMID 22718903, Free PMC Article
    3. Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. Tomoda T, et al. J Gastroenterol Hepatol, 2012 Apr. PMID 22004425
    4. CCDC41 is required for ciliary vesicle docking to the mother centriole. Joo K, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23530209, Free PMC Article
    5. Centriole distal appendages promote membrane docking, leading to cilia initiation. Tanos BE, et al. Genes Dev, 2013 Jan 15. PMID 23348840, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ciliary transition fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 164 kDa
    Names
    centrosomal protein 164kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427257.1 → NP_001414186.1  centrosomal protein of 164 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J450, D3ZL75
      Related
      ENSRNOP00000022583.5, ENSRNOT00000022583.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      54967621..55031264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082355.2 → XP_038938283.1  centrosomal protein of 164 kDa isoform X5

      UniProtKB/TrEMBL
      A6J450
      Related
      ENSRNOP00000103121.1, ENSRNOT00000162398.1
      Conserved Domains (4) summary
      PHA03307
      Location:320 → 574
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:740 → 1086
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:924 → 1253
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00397
      Location:58 → 87
      WW; WW domain

    2. XM_039082353.2 → XP_038938281.1  centrosomal protein of 164 kDa isoform X3

      UniProtKB/TrEMBL
      A0A8I6A687
      Related
      ENSRNOP00000086564.1, ENSRNOT00000113643.2
      Conserved Domains (2) summary
      COG1196
      Location:1243 → 1589
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00397
      Location:58 → 87
      WW; WW domain

    3. XM_039082354.2 → XP_038938282.1  centrosomal protein of 164 kDa isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:1122 → 1468
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:1306 → 1645
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00397
      Location:58 → 87
      WW; WW domain

    4. XM_039082352.2 → XP_038938280.1  centrosomal protein of 164 kDa isoform X2

      Related
      ENSRNOP00000101338.1, ENSRNOT00000156361.1
      Conserved Domains (2) summary
      COG1196
      Location:1246 → 1592
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00397
      Location:58 → 87
      WW; WW domain

    5. XM_039082351.2 → XP_038938279.1  centrosomal protein of 164 kDa isoform X1

      UniProtKB/TrEMBL
      M0R9A9
      Related
      ENSRNOP00000066074.3, ENSRNOT00000072712.5
      Conserved Domains (2) summary
      COG1196
      Location:1295 → 1641
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00397
      Location:58 → 87
      WW; WW domain
    Nucleotide Protein Strain
    Heading Accession and Version

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