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    Crim1 cysteine rich transmembrane BMP regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crim1provided by RGD
    Official Full Name
    cysteine rich transmembrane BMP regulator 1provided by RGD
    Primary source
    RGD:1308710
    See related
    EnsemblRapid:ENSRNOG00000004208 AllianceGenome:RGD:1308710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable PDZ domain binding activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 161.3), Kidney (RPKM 137.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crim1 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (22447983..22622459, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16695864..16870264, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (788490..962663)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene vitrin Neighboring gene U2 spliceosomal RNA Neighboring gene fasciculation and elongation protein zeta 2 Neighboring gene uncharacterized LOC120103478 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 2 Neighboring gene H3.3 histone A, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich motor neuron 1 protein
    Names
    cysteine rich transmembrane BMP regulator 1 (chordin like)
    cysteine-rich motor neuron 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169103.1 → NP_001162574.1  cysteine-rich motor neuron 1 protein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9W6, D4AEK3
      Related
      ENSRNOP00000005983.4, ENSRNOT00000005983.7
      Conserved Domains (4) summary
      smart00121
      Location:37 → 95
      IB; Insulin growth factor-binding protein homologues
      smart00214
      Location:403 → 456
      VWC; von Willebrand factor (vWF) type C domain
      pfam02822
      Location:567 → 592
      Antistasin; Antistasin family
      cl17735
      Location:819 → 873
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      22447983..22622459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111891.2 → XP_038967819.1  cysteine-rich motor neuron 1 protein isoform X3

      UniProtKB/TrEMBL
      A6H9W6
      Conserved Domains (4) summary
      smart00214
      Location:241 → 294
      VWC; von Willebrand factor (vWF) type C domain
      cl17735
      Location:657 → 711
      VWC; von Willebrand factor type C domain
      pfam00219
      Location:39 → 90
      IGFBP; Insulin-like growth factor binding protein
      pfam02822
      Location:405 → 430
      Antistasin; Antistasin family

    2. XM_006239625.5 → XP_006239687.1  cysteine-rich motor neuron 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5L9, A6H9W6
      Related
      ENSRNOP00000088000.1, ENSRNOT00000094931.2
      Conserved Domains (4) summary
      smart00121
      Location:37 → 95
      IB; Insulin growth factor-binding protein homologues
      smart00214
      Location:322 → 375
      VWC; von Willebrand factor (vWF) type C domain
      pfam02822
      Location:486 → 511
      Antistasin; Antistasin family
      cl17735
      Location:738 → 792
      VWC; von Willebrand factor type C domain

    3. XM_006239623.5 → XP_006239685.1  cysteine-rich motor neuron 1 protein isoform X1

      UniProtKB/TrEMBL
      A6H9W6
      Conserved Domains (4) summary
      smart00121
      Location:37 → 95
      IB; Insulin growth factor-binding protein homologues
      smart00214
      Location:403 → 456
      VWC; von Willebrand factor (vWF) type C domain
      pfam02822
      Location:567 → 592
      Antistasin; Antistasin family
      cl17735
      Location:818 → 872
      VWC; von Willebrand factor type C domain

    4. XM_039111893.2 → XP_038967821.1  cysteine-rich motor neuron 1 protein isoform X5

      Conserved Domains (3) summary
      smart00214
      Location:81 → 134
      VWC; von Willebrand factor (vWF) type C domain
      cl17735
      Location:497 → 551
      VWC; von Willebrand factor type C domain
      pfam02822
      Location:245 → 270
      Antistasin; Antistasin family

    5. XM_039111892.2 → XP_038967820.1  cysteine-rich motor neuron 1 protein isoform X4

      Conserved Domains (3) summary
      smart00214
      Location:118 → 171
      VWC; von Willebrand factor (vWF) type C domain
      cl17735
      Location:534 → 588
      VWC; von Willebrand factor type C domain
      pfam02822
      Location:282 → 307
      Antistasin; Antistasin family
    Nucleotide Protein Strain
    Heading Accession and Version

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