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    Ptk7 protein tyrosine kinase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301242, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ptk7provided by RGD
    Official Full Name
    protein tyrosine kinase 7provided by RGD
    Primary source
    RGD:1310472
    See related
    EnsemblRapid:ENSRNOG00000039976 AllianceGenome:RGD:1310472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of canonical Wnt signaling pathway; and positive regulation of neuron projection development. Predicted to act upstream of or within several processes, including cochlea morphogenesis; heart development; and morphogenesis of an epithelium. Predicted to be located in cell-cell junction and membrane. Predicted to be active in plasma membrane. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 114.4), Uterus (RPKM 97.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptk7 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21849756..21916077)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14352155..14418473)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16662588..16729888)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene kinesin light chain 4 Neighboring gene uncharacterized LOC120094784 Neighboring gene serum response factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinase. Jung JW, et al. Gene, 2004 Mar 17. PMID 15019986
    2. Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling. Puppo F, et al. EMBO Rep, 2011 Jan. PMID 21132015, Free PMC Article
    3. The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. Golubkov VS, et al. J Biol Chem, 2010 Nov 12. PMID 20837484, Free PMC Article
    4. Planar cell polarity signaling in vertebrates. Jones C, et al. Bioessays, 2007 Feb. PMID 17226800, Free PMC Article
    5. The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. Paudyal A, et al. BMC Dev Biol, 2010 Aug 12. PMID 20704721, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axis elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cochlea morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within convergent extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of planar polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung-associated mesenchyme development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive tyrosine-protein kinase 7
    Names
    PTK7 protein tyrosine kinase 7
    tyrosine-protein kinase-like 7
    NP_001382670.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395741.1 → NP_001382670.1  inactive tyrosine-protein kinase 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AKN3, A0A8I6ALM9
      Related
      ENSRNOP00000094298.1, ENSRNOT00000108486.2
      Conserved Domains (5) summary
      cd05046
      Location:782 → 1055
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      pfam13927
      Location:585 → 660
      Ig_3; Immunoglobulin domain
      cd00096
      Location:592 → 595
      Ig; Ig strand A' [structural motif]
      cd05760
      Location:120 → 214
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7
      cl11960
      Location:404 → 490
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21849756..21916077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106889.2: Suppressed sequence

      Description
      NM_001106889.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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