Xrcc3 X-ray repair cross complementing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Xrcc3provided by RGD
Official Full Name: X-ray repair cross complementing 3provided by RGD
Primary source: RGD:1306849
See related: EnsemblRapid:ENSRNOG00000012141 AllianceGenome:RGD:1306849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process and regulation of cell cycle process. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of Rad51C-XRCC3 complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); central nervous system cancer (multiple); familial melanoma; multiple myeloma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 33.8), Thymus (RPKM 31.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (136684558..136694822, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (130863405..130873765, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (136366917..136380751, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
contributes_to crossover junction DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to four-way junction DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via synthesis-dependent strand annealing	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in resolution of mitotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info
involved_in resolution of mitotic recombination intermediates	ISO Inferred from Sequence Orthology more info
involved_in t-circle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in t-circle formation	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomere trimming	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in replication fork	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA repair protein XRCC3

Names: X-ray repair complementing defective repair in Chinese hamster cells 3; rCG27697-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427420.2 → NP_001414349.1 DNA repair protein XRCC3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6KBT6, D4A5N4

Related

ENSRNOP00000016208.4, ENSRNOT00000016208.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

136684558..136694822 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240649.4 → XP_006240711.1 DNA repair protein XRCC3 isoform X1

See identical proteins and their annotated locations for XP_006240711.1

UniProtKB/TrEMBL

A6KBT6, D4A5N4

Related

ENSRNOP00000100169.1, ENSRNOT00000149131.1

Conserved Domains (2) summary

cd01123
Location:82 → 337

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

pfam08423
Location:64 → 336

Rad51; Rad51