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    Ewsr1 EWS RNA-binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289752, updated on 9-Dec-2024

    Summary

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    Symbol
    Ewsr1provided by RGD
    Full Name
    EWS RNA-binding protein 1provided by RGD
    Primary source
    RGD:1307258
    See related
    EnsemblRapid:ENSRNOG00000009437 AllianceGenome:RGD:1307258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in Cajal body. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 597.9), Spleen (RPKM 406.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ewsr1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84179413..84208149, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79965365..79994108, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85322105..85350826, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096647 Neighboring gene RAS-like, family 10, member A Neighboring gene growth arrest-specific 2 like 1 Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein. Young PJ, et al. Brain Res Mol Brain Res, 2003 Nov 6. PMID 14597228
    2. A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins. Thomsen C, et al. FASEB J, 2013 Dec. PMID 23975937
    3. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Delattre O, et al. Nature, 1992 Sep 10. PMID 1522903
    4. PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Parvanov ED, et al. Mol Biol Cell, 2017 Feb 1. PMID 27932493, Free PMC Article
    5. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112874

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein EWS
    Names
    Ewing sarcoma breakpoint region 1
    RNA-binding protein EWS-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025632.3 → NP_001020803.2  RNA-binding protein EWS isoform 2

      See identical proteins and their annotated locations for NP_001020803.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K850, A0A9K3Y8I9, B1WC50, F1LN98, F1MA60
      Related
      ENSRNOP00000074472.2, ENSRNOT00000086607.3
      Conserved Domains (3) summary
      sd00025
      Location:521 → 542
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:517 → 546
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:360 → 443
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

    2. NM_001434406.1 → NP_001421335.1  RNA-binding protein EWS isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K850

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84179413..84208149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251203.5 → XP_006251265.2  RNA-binding protein EWS isoform X3

      Related
      ENSRNOP00000012634.7, ENSRNOT00000012634.8
      Conserved Domains (3) summary
      sd00025
      Location:522 → 543
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518 → 547
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:361 → 444
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

    2. XM_006251202.5 → XP_006251264.2  RNA-binding protein EWS isoform X2

      See identical proteins and their annotated locations for XP_006251264.2

      UniProtKB/TrEMBL
      A0A0G2JWK8, A0A140UHY3, A0A8J8Y9N6
      Related
      ENSRNOP00000069920.3, ENSRNOT00000083464.3
      Conserved Domains (4) summary
      PRK12438
      Location:53 → 147
      PRK12438; hypothetical protein; Provisional
      sd00025
      Location:527 → 548
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:523 → 552
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:366 → 449
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

    3. XM_006251201.5 → XP_006251263.2  RNA-binding protein EWS isoform X1

      See identical proteins and their annotated locations for XP_006251263.2

      UniProtKB/TrEMBL
      A0A8J8Y9N6
      Related
      ENSRNOP00000054193.5, ENSRNOT00000057382.6
      Conserved Domains (4) summary
      PRK12438
      Location:53 → 147
      PRK12438; hypothetical protein; Provisional
      sd00025
      Location:528 → 549
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:524 → 553
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:367 → 450
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

    4. XM_063272946.1 → XP_063129016.1  RNA-binding protein EWS isoform X4

    5. XM_039091737.2 → XP_038947665.1  RNA-binding protein EWS isoform X6

      UniProtKB/TrEMBL
      Q4KM41
      Conserved Domains (3) summary
      sd00025
      Location:183 → 204
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:179 → 208
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:22 → 105
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

    6. XM_063272947.1 → XP_063129017.1  RNA-binding protein EWS isoform X5

    7. XM_008770260.4 → XP_008768482.3  RNA-binding protein EWS isoform X7

      UniProtKB/TrEMBL
      A0A8I6A3F5
      Related
      ENSRNOP00000085477.1, ENSRNOT00000094261.2
    Nucleotide Protein Strain
    Heading Accession and Version

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