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    Lalba lactalbumin, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24528, updated on 27-Dec-2024

    Summary

    Official Symbol
    Lalbaprovided by RGD
    Official Full Name
    lactalbumin, alphaprovided by RGD
    Primary source
    RGD:2987
    See related
    EnsemblRapid:ENSRNOG00000010811 AllianceGenome:RGD:2987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lactose synthase activity and lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and lactose biosynthetic process. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Orthologous to human LALBA (lactalbumin alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 5.1), Testes (RPKM 4.0) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Lalba in Genome Data Viewer
    Location:
    7q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131504572..131520707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129625531..129628034, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140088420..140096347, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479784 Neighboring gene olfactory receptor family 5 subfamily BS member 2, pseudogene 1 Neighboring gene olfactory receptor pseudogene 1110 Neighboring gene olfactory receptor family 11 subfamily M member 3 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene KAT8 regulatory NSL complex subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lactose synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lactose synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lactose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-lactalbumin
    Names
    lactose synthase B protein
    NP_036726.1
    XP_063119053.1
    XP_063119054.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012594.2NP_036726.1  alpha-lactalbumin precursor

      See identical proteins and their annotated locations for NP_036726.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007, V01251
      UniProtKB/Swiss-Prot
      P00714, P00715
      Related
      ENSRNOP00000014457.1, ENSRNOT00000014456.5
      Conserved Domains (1) summary
      pfam00062
      Location:20137
      Lys; C-type lysozyme/alpha-lactalbumin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131504572..131520707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262984.1XP_063119054.1  alpha-lactalbumin isoform X1

      UniProtKB/TrEMBL
      F1M7M1
    2. XM_063262983.1XP_063119053.1  alpha-lactalbumin isoform X1

      UniProtKB/TrEMBL
      F1M7M1