Crhr1 corticotropin releasing hormone receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crhr1provided by RGD
Official Full Name: corticotropin releasing hormone receptor 1provided by RGD
Primary source: RGD:61276
See related: EnsemblRapid:ENSRNOG00000004900 AllianceGenome:RGD:61276
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CRF1; CRF-R; CRFR1; CRH-R; CRF-R1; CRFR-1; CRH-R1; CRF-R-1; CRH-R 1; CRH-R-1
Summary: This gene encodes a member of the G-protein coupled receptor family. The encoded protein is a receptor for corticotropin-releasing factor (CRH) and urocortin (UCN). The interaction of this protein with CRH and UCN triggers G-protein coupled signaling. This protein plays a pivotal role in mediating the CRH-elicited effects in depression and anxiety. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Expression: Restricted expression toward (RPKM 31.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (89540192..89583466)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (89040186..89083481)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (92191473..92233662)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring.
Title: Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring.
CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia.
Title: CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia.
Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief.
Title: Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief.
Activation of CRF1 receptors expressed in brainstem autonomic nuclei stimulates colonic enteric neurons and secreto-motor function in male rats.
Title: Activation of CRF(1) receptors expressed in brainstem autonomic nuclei stimulates colonic enteric neurons and secreto-motor function in male rats.
Ventromedial prefrontal cortex CRF1 receptors modulate the tachycardic activity of baroreflex.
Title: Ventromedial prefrontal cortex CRF1 receptors modulate the tachycardic activity of baroreflex.
Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats.
Title: Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats.
Social isolation of adolescent male rats increases anxiety and K(+) -induced dopamine release in the nucleus accumbens: Role of CRF-R1.
Title: Social isolation of adolescent male rats increases anxiety and K(+) -induced dopamine release in the nucleus accumbens: Role of CRF-R1.
Sex differences in corticotropin releasing factor peptide regulation of inhibitory control and excitability in central amygdala corticotropin releasing factor receptor 1-neurons.
Title: Sex differences in corticotropin releasing factor peptide regulation of inhibitory control and excitability in central amygdala corticotropin releasing factor receptor 1-neurons.
Results demonstrate that corticotropin-releasing factor excites the lateral vestibular nuclear (LVN) neurons by co-activation of both CRF receptors 1 and CRF receptors 2, suggesting that via the direct modulation on the LVN.
Title: Corticotropin-releasing factor depolarizes rat lateral vestibular nuclear neurons through activation of CRF receptors 1 and 2.
Stress-induced reinstatement, in a model of cocaine seeking relapse, is mediated by CRFR1-regulated dopaminergic projection from the ventral tegmental area to the prefrontal cortex.
Title: Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497466

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497467

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497475

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497477

UniSTS:497478 (e-PCR)
- UniSTS:497478

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497478

GDB:572888 (e-PCR)
- UniSTS:157778

AW531488 (e-PCR)
- UniSTS:245108

D10Chm230 (e-PCR)
- UniSTS:518344

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables corticotrophin-releasing factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotrophin-releasing factor receptor activity	IEA Inferred from Electronic Annotation more info
enables corticotrophin-releasing factor receptor activity	ISO Inferred from Sequence Orthology more info
enables corticotrophin-releasing factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables corticotropin-releasing hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adrenal gland development	IEA Inferred from Electronic Annotation more info
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to corticotropin-releasing hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticotropin-releasing hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in corticotropin secretion	IEA Inferred from Electronic Annotation more info
involved_in corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in corticotropin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exploration behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in fear response	IEA Inferred from Electronic Annotation more info
involved_in fear response	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in general adaptation syndrome, behavioral process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within general adaptation syndrome, behavioral process	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of corticosterone secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of corticosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of corticosterone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to electrical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
NOT located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: corticotropin-releasing factor receptor 1

Names: corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301812.3 → NP_001288741.3 corticotropin-releasing factor receptor 1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8L2Q2C2, B3SXS3
NM_030999.6 → NP_112261.3 corticotropin-releasing factor receptor 1 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P35353

UniProtKB/TrEMBL

A0A8L2Q2C2, A6HJT9

Related

ENSRNOP00000006764.7, ENSRNOT00000006764.9

RNA

NR_126013.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate splice site in an internal region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

JAXUCZ010000010
NR_126014.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

JAXUCZ010000010