Phkg1 phosphorylase kinase catalytic subunit gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phkg1provided by RGD
Official Full Name: phosphorylase kinase catalytic subunit gamma 1provided by RGD
Primary source: RGD:3325
See related: EnsemblRapid:ENSRNOG00000000920 AllianceGenome:RGD:3325
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Phkg; PHKIN01
Summary: Enables ATP binding activity; enzyme binding activity; and phosphorylase kinase activity. Involved in glycogen metabolic process and protein phosphorylation. Part of phosphorylase kinase complex. Orthologous to human PHKG1 (phosphorylase kinase catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 1156.5) and Heart (RPKM 84.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32474926..32490657)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26838822..26854547)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30450431..30464314)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Phkg1 (e-PCR), detects polymorphism
- UniSTS:507138

RH94823 (e-PCR)
- UniSTS:120069

AI711004 (e-PCR)
- UniSTS:243811

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphorylase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorylase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorylase kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphorylase kinase activity	ISO Inferred from Sequence Orthology more info
enables phosphorylase kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in glycogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphorylase kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphorylase kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of phosphorylase kinase complex	IEA Inferred from Electronic Annotation more info
part_of phosphorylase kinase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

Names: gamma phosphorylase kinase; phosphorylase kinase subunit gamma-1; phosphorylase kinase, gamma 1; serine/threonine-protein kinase PHKG1

NP_113761.1

EC 2.7.11.1

EC 2.7.11.19

EC 2.7.11.26

XP_038945214.1

EC 2.7.11.1

EC 2.7.11.19

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031573.2 → NP_113761.1 phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

See identical proteins and their annotated locations for NP_113761.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P13286

UniProtKB/TrEMBL

A0A8I5ZWH7, A6J0P5

Related

ENSRNOP00000001222.1, ENSRNOT00000001222.6

Conserved Domains (1) summary

cl21453
Location:16 → 291

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

32474926..32490657

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089286.2 → XP_038945214.1 phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

UniProtKB/TrEMBL

A0A8I5ZWH7

Conserved Domains (1) summary

cl21453
Location:16 → 281

PKc_like; Protein Kinases, catalytic domain