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    Wwc2 WW and C2 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wwc2provided by RGD
    Official Full Name
    WW and C2 domain containing 2provided by RGD
    Primary source
    RGD:1559427
    See related
    EnsemblRapid:ENSRNOG00000013248 AllianceGenome:RGD:1559427
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559427
    Summary
    Predicted to enable kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including hippo signaling; negative regulation of hippo signaling; and negative regulation of organ growth. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC2 (WW and C2 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 189.5), Lung (RPKM 113.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wwc2 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (50991096..51154529)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44258372..44421815)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47368768..47533816)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a, pseudogene 8 Neighboring gene uncharacterized LOC102551022 Neighboring gene uncharacterized LOC134482501 Neighboring gene claudin 22 Neighboring gene claudin 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, et al. Mol Biol Evol, 2014 Jul. PMID 24682284
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of organ growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein WWC2
    Names
    WW, C2 and coiled-coil domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109111.1 → NP_001102581.1  protein WWC2

      See identical proteins and their annotated locations for NP_001102581.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473995
      UniProtKB/TrEMBL
      A6JPK1, D4AEJ5
      Related
      ENSRNOP00000017966.4, ENSRNOT00000017966.7
      Conserved Domains (5) summary
      cd08680
      Location:699 → 822
      C2_Kibra; C2 domain found in Human protein Kibra
      pfam00397
      Location:12 → 41
      WW; WW domain
      pfam11068
      Location:351 → 420
      YlqD; YlqD protein
      cl01720
      Location:1095 → 1153
      Phage_Nu1; Phage DNA packaging protein Nu1
      cl19219
      Location:283 → 385
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      50991096..51154529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275643.1 → XP_063131713.1  protein WWC2 isoform X1

      Related
      ENSRNOP00000109755.1, ENSRNOT00000162186.1

    2. XM_063275644.1 → XP_063131714.1  protein WWC2 isoform X2

    3. XM_039094772.2 → XP_038950700.1  protein WWC2 isoform X3

      Conserved Domains (3) summary
      cd08680
      Location:515 → 638
      C2_Kibra; C2 domain found in Human protein Kibra
      COG1196
      Location:7 → 231
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd06503
      Location:897 → 984
      ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
    Nucleotide Protein Strain
    Heading Accession and Version

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