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    Aamdc adipogenesis associated, Mth938 domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361606, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Aamdcprovided by RGD
    Official Full Name
    adipogenesis associated, Mth938 domain containingprovided by RGD
    Primary source
    RGD:1561459
    See related
    EnsemblRapid:ENSRNOG00000012584 AllianceGenome:RGD:1561459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561459
    Summary
    Predicted to be involved in positive regulation of fat cell differentiation. Predicted to act upstream of or within negative regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm. Orthologous to human AAMDC (adipogenesis associated Mth938 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 116.4), Testes (RPKM 106.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aamdc in Genome Data Viewer
    Location:
    1q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161273205..161303253, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151861990..151893621, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162519513..162549211, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene integrator complex subunit 4 Neighboring gene remodeling and spacing factor 1 Neighboring gene ribosomal protein L35, pseudogene 4 Neighboring gene chloride nucleotide-sensitive channel 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of LOC66273 isoform 2, a novel Mth938 containing protein, in MAPK pathway. Wang H, et al. Front Biosci (Elite Ed), 2011 Jun 1. PMID 21622130
    2. LOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cells. Ma X, et al. J Nutr, 2012 Mar. PMID 22279136
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mth938 domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108493.1 → NP_001101963.1  mth938 domain-containing protein

      See identical proteins and their annotated locations for NP_001101963.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A0A8I6GF83, A6I6A6
      Related
      ENSRNOP00000016783.6, ENSRNOT00000016783.8
      Conserved Domains (1) summary
      cd05126
      Location:7 → 122
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      161273205..161303253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589374.3 → XP_017444863.1  mth938 domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GF83, A6I6A6
      Conserved Domains (1) summary
      cd05126
      Location:7 → 122
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

    2. XM_006229768.4 → XP_006229830.1  mth938 domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006229830.1

      UniProtKB/TrEMBL
      A0A8I6GF83, A6I6A6
      Related
      ENSRNOP00000089158.1, ENSRNOT00000099902.2
      Conserved Domains (1) summary
      cd05126
      Location:7 → 122
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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