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    Zfp143 zinc finger protein 143 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp143provided by RGD
    Official Full Name
    zinc finger protein 143provided by RGD
    Primary source
    RGD:1305662
    See related
    EnsemblRapid:ENSRNOG00000010087 AllianceGenome:RGD:1305662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    STAF; Znf143
    Summary
    Enables chromatin binding activity. Involved in positive regulation of smooth muscle cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 49.5), Spleen (RPKM 41.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp143 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173543810..173579667)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164109041..164144902)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174702310..174738133)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein, pseudogene 5 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC134483773 Neighboring gene RNA, U6 small nuclear 1168 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene switching B-cell complex subunit SWAP70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription-activating factor (STAF). Hernández-Negrete I, et al. Biochem J, 2011 May 15. PMID 21352097, Free PMC Article
    2. Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA gene transcription activating factor family zinc finger proteins. Kubota H, et al. J Biol Chem, 2000 Sep 15. PMID 10893243
    3. Regulation of aldehyde reductase expression by STAF and CHOP. Barski OA, et al. Genomics, 2004 Jan. PMID 14667815
    4. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 143
    Names
    selenocysteine tRNA gene transcription-activating factor
    zfp-143
    NP_001012169.2
    XP_006230056.1
    XP_038938655.1
    XP_063123513.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012169.3 → NP_001012169.2  zinc finger protein 143

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5XIU2
      UniProtKB/TrEMBL
      A0A0H2UHI0, A6I808
      Related
      ENSRNOP00000013733.9, ENSRNOT00000013733.7
      Conserved Domains (3) summary
      COG5048
      Location:251 → 424
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207 → 292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      173543810..173579667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229994.3 → XP_006230056.1  zinc finger protein 143 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHI0
      Conserved Domains (3) summary
      sd00017
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312 → 339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298 → 413
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_039082727.2 → XP_038938655.1  zinc finger protein 143 isoform X2

      UniProtKB/Swiss-Prot
      Q5XIU2
      UniProtKB/TrEMBL
      A0A0H2UHI0, A6I808
      Related
      ENSRNOP00000109958.1, ENSRNOT00000140259.1
      Conserved Domains (3) summary
      COG5048
      Location:251 → 424
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207 → 292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_063267443.1 → XP_063123513.1  zinc finger protein 143 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHI0
      Related
      ENSRNOP00000077653.1, ENSRNOT00000119146.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIU2.2 GenPept UniProtKB/Swiss-Prot:Q5XIU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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