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    Vstm2l V-set and transmembrane domain containing 2 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vstm2lprovided by RGD
    Official Full Name
    V-set and transmembrane domain containing 2 likeprovided by RGD
    Primary source
    RGD:1305725
    See related
    AllianceGenome:RGD:1305725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305725
    Summary
    Involved in negative regulation of neuron apoptotic process. Located in cytoplasm and extracellular region. Orthologous to human VSTM2L (V-set and transmembrane domain containing 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 120.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vstm2l in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166991035..167020869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (146571099..146600930)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (154395014..154424482)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene catenin, beta like 1 Neighboring gene mitochondrial pyruvate carrier 1-like, pseudogene 3 Neighboring gene uncharacterized LOC134486468 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene TELO2 interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin. Rossini L, et al. FASEB J, 2011 Jun. PMID 21393573
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-set and transmembrane domain-containing protein 2-like protein; similar to chromosome 20 open reading frame 102
    Names
    gene model 691,-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430743.1 → NP_001417672.1  similar to chromosome 20 open reading frame 102 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZDJ6

    2. NM_001430744.1 → NP_001417673.1  similar to chromosome 20 open reading frame 102 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      166991035..167020869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285125.1 → XP_063141195.1  V-set and transmembrane domain-containing protein 2-like protein isoform X2

    2. XM_342561.10 → XP_342562.5  V-set and transmembrane domain-containing protein 2-like protein isoform X1

      Conserved Domains (2) summary
      pfam13927
      Location:43 → 144
      Ig_3; Immunoglobulin domain
      cd00096
      Location:50 → 52
      Ig; Ig strand A' [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials