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    Arhgef37 Rho guanine nucleotide exchange factor 37 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef37provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 37provided by RGD
    Primary source
    RGD:1560471
    See related
    EnsemblRapid:ENSRNOG00000025502 AllianceGenome:RGD:1560471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560471
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in synapse. Predicted to be active in cytoplasm. Orthologous to human ARHGEF37 (Rho guanine nucleotide exchange factor 37). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 53.8), Heart (RPKM 49.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef37 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57205621..57271284, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54935256..55001017, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56817986..56871159, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene PPARG coactivator 1 beta Neighboring gene microRNA 3557 Neighboring gene microRNA 378 Neighboring gene U6 spliceosomal RNA Neighboring gene casein kinase 1, alpha 1 Neighboring gene ribosomal protein S23, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 37
    Names
    Rho guanine nucleotide exchange factor (GEF) 37
    probable guanine nucleotide exchange factor FLJ41603 homolog
    protein 2-88
    scaffold protein tuba 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100974.2 → NP_001094444.2  rho guanine nucleotide exchange factor 37

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      A1IGU3
      UniProtKB/TrEMBL
      F1LQ74
      Related
      ENSRNOP00000037964.2, ENSRNOT00000032189.5
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:607 → 663
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 211
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      57205621..57271284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254811.5 → XP_006254873.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_006254873.1

      UniProtKB/Swiss-Prot
      A1IGU3
      UniProtKB/TrEMBL
      F1LQ74
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:607 → 663
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 211
      RhoGEF; RhoGEF domain

    2. XM_039096828.2 → XP_038952756.1  rho guanine nucleotide exchange factor 37 isoform X1

      UniProtKB/Swiss-Prot
      A1IGU3
      UniProtKB/TrEMBL
      F1LQ74
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:607 → 663
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 211
      RhoGEF; RhoGEF domain

    3. XM_006254809.4 → XP_006254871.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_006254871.1

      UniProtKB/Swiss-Prot
      A1IGU3
      UniProtKB/TrEMBL
      F1LQ74
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:607 → 663
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 211
      RhoGEF; RhoGEF domain

    4. XM_039096832.2 → XP_038952760.1  rho guanine nucleotide exchange factor 37 isoform X2

      Conserved Domains (3) summary
      cd07589
      Location:50 → 238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296 → 349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:393 → 449
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

    5. XM_063277355.1 → XP_063133425.1  rho guanine nucleotide exchange factor 37 isoform X2

    6. XM_039096833.2 → XP_038952761.1  rho guanine nucleotide exchange factor 37 isoform X2

      Conserved Domains (3) summary
      cd07589
      Location:50 → 238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296 → 349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:393 → 449
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

    7. XM_039096835.2 → XP_038952763.1  rho guanine nucleotide exchange factor 37 isoform X3

      Conserved Domains (3) summary
      cd07589
      Location:3 → 164
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:222 → 275
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:319 → 375
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

    RNA

    1. XR_010059573.1 RNA Sequence

    2. XR_010059575.1 RNA Sequence

    3. XR_010059572.1 RNA Sequence

    4. XR_010059574.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1IGU3.1 GenPept UniProtKB/Swiss-Prot:A1IGU3

    Gene LinkOut

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