Rnft1 ring finger protein, transmembrane 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnft1provided by RGD
Official Full Name: ring finger protein, transmembrane 1provided by RGD
Primary source: RGD:1562411
See related: EnsemblRapid:ENSRNOG00000003805 AllianceGenome:RGD:1562411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnft1-ps1; RGD1562411
Summary: Predicted to enable ubiquitin binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway and protein autoubiquitination. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human RNFT1 (ring finger protein, transmembrane 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 173.9), Spleen (RPKM 173.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (71807403..71821132)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (71310052..71322507)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (73807455..73821178)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D10Chm224 (e-PCR)
- UniSTS:518173

RH139016 (e-PCR)
- UniSTS:221102

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNFT1

Names: RING finger and transmembrane domain-containing protein 1; ring finger protein, transmembrane 1, pseudogene 1

NP_001385733.1

EC 2.3.2.27

XP_006247182.1

EC 2.3.2.27

XP_063125472.1

EC 2.3.2.27

XP_063125473.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398804.1 → NP_001385733.1 E3 ubiquitin-protein ligase RNFT1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZUV7, D3ZG84

Related

ENSRNOP00000005064.4, ENSRNOT00000005064.7

Conserved Domains (2) summary

cd00162
Location:337 → 374

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cl17238
Location:336 → 375

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

71807403..71821132

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269403.1 → XP_063125473.1 E3 ubiquitin-protein ligase RNFT1 isoform X3
XM_006247120.5 → XP_006247182.1 E3 ubiquitin-protein ligase RNFT1 isoform X2

See identical proteins and their annotated locations for XP_006247182.1

UniProtKB/TrEMBL

D3ZG84

Conserved Domains (1) summary

cd00162
Location:284 → 325

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_063269402.1 → XP_063125472.1 E3 ubiquitin-protein ligase RNFT1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUV7, D3ZG84