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    Rpl7 ribosomal protein L7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpl7provided by RGD
    Official Full Name
    ribosomal protein L7provided by RGD
    Primary source
    RGD:735169
    See related
    EnsemblRapid:ENSRNOG00000084049 AllianceGenome:RGD:735169
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 5S rRNA binding activity. Involved in liver regeneration. Located in A band and ribosome. Part of cytosolic large ribosomal subunit. Orthologous to human RPL7 (ribosomal protein L7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 6879.8), Thymus (RPKM 6273.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl7 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (8000446..8003454)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (3217184..3220192)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (2633517..2636525)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene uncharacterized LOC102555040 Neighboring gene uncharacterized LOC134486911 Neighboring gene retinol dehydrogenase 10 Neighboring gene similar to human chromosome 8 open reading frame 89 Neighboring gene uncharacterized LOC134486912 Neighboring gene ribosomal protein S8-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The primary structure of rat ribosomal protein L7. The presence near the amino terminus of L7 of five tandem repeats of a sequence of 12 amino acids. Lin A, et al. J Biol Chem, 1987 Sep 15. PMID 3624274
    2. Studies on interaction of 5 S RNA with ribosomal proteins. Kärgel HJ, et al. FEBS Lett, 1987 Aug 10. PMID 3301408
    3. Immunological localization of ribosomes in striated rat muscle. Evidence for myofibrillar association and ontological changes in the subsarcolemmal:myofibrillar distribution. Horne Z, et al. Biochem J, 1990 May 15. PMID 2188648, Free PMC Article
    4. The primary structures of rat ribosomal proteins: the characterization of the cDNAs for S21 and L39, corrections in the sequences of L7 and L18a, and the identification of L33. Chan YL, et al. Biochem Biophys Res Commun, 1995 Aug 24. PMID 7654221
    5. Structural and functional properties of ribosomal protein L7 from humans and rodents. Hemmerich P, et al. Nucleic Acids Res, 1993 Jan 25. PMID 8441630, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL30
    Names
    60S ribosomal protein L7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100534.1 → NP_001094004.1  large ribosomal subunit protein uL30

      See identical proteins and their annotated locations for NP_001094004.1

      Status: PROVISIONAL

      Source sequence(s)
      BC159431
      UniProtKB/Swiss-Prot
      P05426
      UniProtKB/TrEMBL
      B0K031
      Related
      ENSRNOP00000102004.1, ENSRNOT00000147749.1
      Conserved Domains (3) summary
      cd01657
      Location:101 → 260
      Ribosomal_L7_archeal_euk; Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The ...
      TIGR01310
      Location:28 → 260
      uL30_euk; 60S ribosomal protein uL30, eukaryotic form
      pfam08079
      Location:29 → 99
      Ribosomal_L30_N; Ribosomal L30 N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      8000446..8003454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05426.2 GenPept UniProtKB/Swiss-Prot:P05426

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.