Zfp36l2 zinc finger protein 36, C3H type-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Zfp36l2provided by RGD
Full Name: zinc finger protein 36, C3H type-like 2provided by RGD
Primary source: RGD:1308913
See related: EnsemblRapid:ENSRNOG00000005067 AllianceGenome:RGD:1308913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; hemopoiesis; and positive regulation of mRNA catabolic process. Predicted to act upstream of or within hemopoiesis and nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Orthologous to human ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 60.3), Spleen (RPKM 60.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (16242622..16246662)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (10490032..10494073)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (7417416..7423447, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D2S2709 (e-PCR)
- UniSTS:31039

AW434453 (e-PCR)
- UniSTS:248777

RH141450 (e-PCR)
- UniSTS:223444

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in definitive hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in somatic stem cell division	ISO Inferred from Sequence Orthology more info
involved_in somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA decay activator protein ZFP36L2

Names: butyrate response factor 2; zinc finger protein 36, C3H1 type-like 2; zinc finger protein 36, C3H1 type-like 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001036626.3 → NP_001031703.2 mRNA decay activator protein ZFP36L2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6H9J7, D3ZHK9

Related

ENSRNOP00000006725.5, ENSRNOT00000006725.7

Conserved Domains (2) summary

COG5063
Location:152 → 214

CTH1; CCCH-type Zn-finger protein [General function prediction only]

pfam04553
Location:1 → 129

Tis11B_N; Tis11B like protein, N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

16242622..16246662

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765049.3 → XP_008763271.1 mRNA decay activator protein ZFP36L2 isoform X1

UniProtKB/TrEMBL

A6H9J7

Conserved Domains (2) summary

pfam00642
Location:164 → 189

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam04553
Location:3 → 141

Tis11B_N; Tis11B like protein, N terminus