Clint1 clathrin interactor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clint1provided by RGD
Official Full Name: clathrin interactor 1provided by RGD
Primary source: RGD:1303328
See related: EnsemblRapid:ENSRNOG00000005406 AllianceGenome:RGD:1303328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Enth; Epn4; Clint
Summary: Enables clathrin binding activity. Involved in clathrin coat assembly. Located in clathrin-coated vesicle. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 199.1), Adrenal (RPKM 129.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (30799936..30854513)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (30298618..30353185)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (30833914..31007813)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clint/epsinR/enthoprotin has been identified in the Golgi region of spermatocytes.
Title: The clathrin interacting protein Clint/epsinR in rat testicular germ cells.
a novel clathrin-associated protein - enthoprotin ((Enth) identified through subcellular proteomics; data suggest a role in clathrin-mediated budding on internal membranes.
Title: Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI642036 (e-PCR)
- UniSTS:164460

D10Got51 (e-PCR)
- UniSTS:112269

MARC_9845-9846:996688657:1 (e-PCR)
- UniSTS:270016

stSG610605 (e-PCR)
- UniSTS:448742

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in clathrin coat assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: clathrin interactor 1

Names: enthoprotin; epsin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415157.1 → NP_001402086.1 clathrin interactor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5Y9G0

Related

ENSRNOP00000069793.3, ENSRNOT00000079437.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

30799936..30854513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767689.3 → XP_008765911.2 clathrin interactor 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JW94, A0A8I5Y9G0

Conserved Domains (2) summary

pfam09606
Location:507 → 634

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16989
Location:24 → 149

ENTH_EpsinR; Epsin N-Terminal Homology (ENTH) domain of Epsin-related protein