Bcar3 BCAR3 adaptor protein, NSP family member [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcar3provided by RGD
Official Full Name: BCAR3 adaptor protein, NSP family memberprovided by RGD
Primary source: RGD:1311688
See related: EnsemblRapid:ENSRNOG00000013737 AllianceGenome:RGD:1311688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable kinase binding activity and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; endothelin receptor signaling pathway; and positive regulation of GTPase activity. Predicted to act upstream of or within lens morphogenesis in camera-type eye and positive regulation of peptidyl-serine phosphorylation. Predicted to be located in focal adhesion and membrane. Orthologous to human BCAR3 (BCAR3 adaptor protein, NSP family member). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 69.4), Spleen (RPKM 64.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (213209907..213323305)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (210525260..210638674)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (226563050..226679449)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration
Title: Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.

Submit: New GeneRIF Correction

General gene information

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Markers

RH136843 (e-PCR)
- UniSTS:218932

D2Got146 (e-PCR)
- UniSTS:114132

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endothelin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lens morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: breast cancer anti-estrogen resistance protein 3 homolog

Names: BCAR3 adapter protein, NSP family member; BCAR3, NSP family adaptor protein 3; SH2 domain-containing protein 3B; breast cancer anti-estrogen resistance 3; novel SH2-containing protein 2; p130Cas-binding protein AND-34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107722.1 → NP_001101192.1 breast cancer anti-estrogen resistance protein 3 homolog

See identical proteins and their annotated locations for NP_001101192.1

Status: PROVISIONAL

Source sequence(s)

CH473952

UniProtKB/Swiss-Prot

D3ZAZ5

UniProtKB/TrEMBL

A0A8I5Y0X0

Related

ENSRNOP00000062880.1, ENSRNOT00000065111.3

Conserved Domains (2) summary

cd10337
Location:148 → 282

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:544 → 819

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

213209907..213323305

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102442.2 → XP_038958370.1 breast cancer anti-estrogen resistance protein 3 homolog isoform X1

UniProtKB/Swiss-Prot

D3ZAZ5

UniProtKB/TrEMBL

A0A8I5Y0X0

Related

ENSRNOP00000076885.1, ENSRNOT00000107706.2

Conserved Domains (2) summary

cd10337
Location:148 → 282

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:544 → 819

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_006233270.5 → XP_006233332.1 breast cancer anti-estrogen resistance protein 3 homolog isoform X2

UniProtKB/TrEMBL

A0A8I5Y0X0

Conserved Domains (2) summary

cd10337
Location:57 → 191

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:453 → 728

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...