Dennd10 DENN domain containing 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dennd10provided by RGD
Official Full Name: DENN domain containing 10provided by RGD
Primary source: RGD:1308326
See related: EnsemblRapid:ENSRNOG00000010230 AllianceGenome:RGD:1308326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam45a; RGD1308326
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Predicted to be active in late endosome. Orthologous to several human genes including DENND10 (DENN domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 160.4), Kidney (RPKM 108.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (269937023..269960506)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (259950955..259974459)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (282188080..282211588)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138686 (e-PCR)
- UniSTS:220773

RH138824 (e-PCR)
- UniSTS:220911

BE109682 (e-PCR)
- UniSTS:248319

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosome transport via multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DENN domain-containing protein 10

Names: family with sequence similarity 45, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.