Snx4 sorting nexin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snx4provided by RGD
Official Full Name: sorting nexin 4provided by RGD
Primary source: RGD:1309763
See related: EnsemblRapid:ENSRNOG00000001786 AllianceGenome:RGD:1309763
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of autophagosome assembly; and positive regulation of histamine secretion by mast cell. Predicted to be located in cytoplasm and membrane. Predicted to be part of SNARE complex and cytoplasmic dynein complex. Predicted to be active in early endosome membrane; plasma membrane; and presynaptic endosome. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 197.4), Brain (RPKM 166.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (80965965..81023234, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (67460872..67518143, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (70693381..70753620, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138917 (e-PCR)
- UniSTS:221004

D11Mit11 (e-PCR), detects polymorphism
- UniSTS:260549

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables leptin receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic endosome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127550.1 → NP_001121022.1 sorting nexin-4

See identical proteins and their annotated locations for NP_001121022.1

Status: PROVISIONAL

Source sequence(s)

BC166791

UniProtKB/TrEMBL

B2RYI6, E9PU13

Related

ENSRNOP00000002432.7, ENSRNOT00000002432.8

Conserved Domains (3) summary

cd06864
Location:58 → 184

PX_SNX4; The phosphoinositide binding Phox Homology domain of Sorting Nexin 4

cd07622
Location:205 → 448

BAR_SNX4; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4

pfam11221
Location:324 → 398

Med21; Subunit 21 of Mediator complex