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    Dhrs3 dehydrogenase/reductase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhrs3provided by RGD
    Official Full Name
    dehydrogenase/reductase 3provided by RGD
    Primary source
    RGD:1305584
    See related
    EnsemblRapid:ENSRNOG00000015736 AllianceGenome:RGD:1305584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be active in lipid droplet. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 586.1), Adrenal (RPKM 434.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhrs3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (162031853..162065655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (156747939..156782420)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (162809090..162843385)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L9 pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC102550246 Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene ribosomal protein L36, pseudogene Neighboring gene TNF receptor superfamily member 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DHRS3, a retinal reductase, is differentially regulated by retinoic acid and lipopolysaccharide-induced inflammation in THP-1 cells and rat liver. Zolfaghari R, et al. Am J Physiol Gastrointest Liver Physiol, 2012 Sep 1. PMID 22790594, Free PMC Article
    2. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. Billings SE, et al. FASEB J, 2013 Dec. PMID 24005908, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125166

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    short-chain dehydrogenase/reductase 3
    Names
    dehydrogenase/reductase (SDR family) member 3
    dehydrogenase/reductase member 2
    retinal dehydrogenase/reductase family member 3
    NP_001032276.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037199.3 → NP_001032276.3  short-chain dehydrogenase/reductase 3

      See identical proteins and their annotated locations for NP_001032276.3

      Status: PROVISIONAL

      Source sequence(s)
      BC107450
      UniProtKB/TrEMBL
      A1YR15, A6IU09, F7FCZ4, Q3B7V0
      Related
      ENSRNOP00000021155.6, ENSRNOT00000021155.7
      Conserved Domains (2) summary
      cd05339
      Location:53 → 281
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      PRK09072
      Location:35 → 288
      PRK09072; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      162031853..162065655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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