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    Epha10 EPH receptor A10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epha10provided by RGD
    Official Full Name
    EPH receptor A10provided by RGD
    Primary source
    RGD:1562679
    See related
    EnsemblRapid:ENSRNOG00000037340 AllianceGenome:RGD:1562679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562679
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be active in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human EPHA10 (EPH receptor A10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 42.0) and Testes (RPKM 12.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epha10 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142424260..142460305)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137139588..137175637)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (142875171..142910537)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 89 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene U6 spliceosomal RNA Neighboring gene cell division cycle associated 8 Neighboring gene AFG2 interacting ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Aasheim HC, et al. Biochim Biophys Acta, 2005 May 25. PMID 15777695
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane-ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 10
    NP_001382024.1
    XP_017448782.1
    XP_038965557.1
    XP_063143510.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395095.1 → NP_001382024.1  ephrin type-A receptor 10 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1LX55
      Related
      ENSRNOP00000053334.6, ENSRNOT00000056496.6
      Conserved Domains (6) summary
      cd09549
      Location:928 → 997
      SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
      cd00063
      Location:451 → 551
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:339 → 431
      fn3; Fibronectin type III domain
      pfam14575
      Location:568 → 641
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl21453
      Location:638 → 902
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      142424260..142460305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593293.3 → XP_017448782.1  ephrin type-A receptor 10 isoform X3

      UniProtKB/TrEMBL
      A6IS59

    2. XM_039109629.2 → XP_038965557.1  ephrin type-A receptor 10 isoform X1

      UniProtKB/TrEMBL
      F1LX55
      Conserved Domains (6) summary
      cd09549
      Location:982 → 1051
      SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
      cd00063
      Location:451 → 551
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:339 → 431
      fn3; Fibronectin type III domain
      pfam14575
      Location:568 → 641
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl21453
      Location:638 → 956
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063287440.1 → XP_063143510.1  ephrin type-A receptor 10 isoform X2

    RNA

    1. XR_005504408.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001135709.2: Suppressed sequence

      Description
      NM_001135709.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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