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    Zfand6 zinc finger AN1-type containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfand6provided by RGD
    Official Full Name
    zinc finger AN1-type containing 6provided by RGD
    Primary source
    RGD:1359317
    See related
    EnsemblRapid:ENSRNOG00000013506 AllianceGenome:RGD:1359317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Za20d3; zgc:101121
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including cellular response to tumor necrosis factor; protein targeting to peroxisome; and regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Orthologous to human ZFAND6 (zinc finger AN1-type containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 182.5), Spleen (RPKM 176.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfand6 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (147990099..148061221, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (138581002..138652052, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (146745850..146823762, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cortexin domain containing 1 Neighboring gene fumarylacetoacetate hydrolase Neighboring gene uncharacterized LOC134485144 Neighboring gene RNA, U6 small nuclear 891 Neighboring gene uncharacterized LOC134485145 Neighboring gene uncharacterized LOC134485146

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats. Zhan J, et al. J Neuroinflammation, 2016 Oct 3. PMID 27716383, Free PMC Article
    2. Zinc finger protein A20 inhibits maturation of dendritic cells resident in rat liver allograft. Dai FZ, et al. J Surg Res, 2013 Aug. PMID 23481562
    3. Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain. Peluffo H, et al. Neurol Res, 2013 Apr. PMID 23336395
    4. The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. Lutz J, et al. J Mol Med (Berl), 2008 Dec. PMID 18813897
    5. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. Chang EJ, et al. Int J Biochem Cell Biol, 2011 Nov. PMID 21810480

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that the Ischemia/reperfusion cortical neurons in MCAO rats are the main cell types that express A20, and there is a correlation between A20 expression and the suppression of neuroinflammation and the resulting neuroprotective effects.
      Title: Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats.
    2. Zinc finger protein A20 inhibits maturation of dendritic cells resident in rat liver allograft.
      Title: Zinc finger protein A20 inhibits maturation of dendritic cells resident in rat liver allograft.
    3. A20 is expressed in astrocytes after brain damage, and its overexpression is neurotoxic for cortical neurons in basal mixed neuron-glia culture conditions and exacerbates postnatal brain excitotoxic damage.
      Title: Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain.
    4. It was observed that A20 was induced in rat kidneys exposed to ischaemia/reperfusion.
      Title: The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94805

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 6
    Names
    protein associated with PRK1
    zinc finger A20 domain-containing protein 3
    zinc finger, A20 domain containing 3
    zinc finger, AN1-type domain 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007630.1 → NP_001007631.1  AN1-type zinc finger protein 6

      See identical proteins and their annotated locations for NP_001007631.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076394
      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      147990099..148061221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229507.4 → XP_006229569.1  AN1-type zinc finger protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006229569.1

      UniProtKB/TrEMBL
      A0A8I6A8E7, A6JCP2
      Conserved Domains (2) summary
      smart00154
      Location:149 → 186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    2. XM_039105750.2 → XP_038961678.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    3. XM_063284852.1 → XP_063140922.1  AN1-type zinc finger protein 6 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8E7
      Related
      ENSRNOP00000088600.2, ENSRNOT00000099671.2

    4. XM_006229505.3 → XP_006229567.1  AN1-type zinc finger protein 6 isoform X2

      See identical proteins and their annotated locations for XP_006229567.1

      UniProtKB/TrEMBL
      A0A8I5YCN4, A0A8I6AJP8
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    5. XM_063284856.1 → XP_063140926.1  AN1-type zinc finger protein 6 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8E7

    6. XM_063284824.1 → XP_063140894.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YCN4, A0A8I6AJP8
      Related
      ENSRNOP00000095451.1, ENSRNOT00000100459.2

    7. XM_063284840.1 → XP_063140910.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8E7, A6JCP2

    8. XM_017588943.3 → XP_017444432.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    9. XM_063284854.1 → XP_063140924.1  AN1-type zinc finger protein 6 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8E7

    10. XM_063284837.1 → XP_063140907.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YCN4, A0A8I6AJP8

    11. XM_063284839.1 → XP_063140909.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8E7, A6JCP2

    12. XM_006229499.4 → XP_006229561.1  AN1-type zinc finger protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006229561.1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    13. XM_063284825.1 → XP_063140895.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YCN4, A0A8I6AJP8

    14. XM_063284841.1 → XP_063140911.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8E7, A6JCP2

    15. XM_006229506.5 → XP_006229568.1  AN1-type zinc finger protein 6 isoform X2

      See identical proteins and their annotated locations for XP_006229568.1

      UniProtKB/TrEMBL
      A0A8I5YCN4, A0A8I6AJP8
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    16. XM_006229508.5 → XP_006229570.1  AN1-type zinc finger protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006229570.1

      UniProtKB/TrEMBL
      A0A8I6A8E7, A6JCP2
      Conserved Domains (2) summary
      smart00154
      Location:149 → 186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    17. XM_006229500.5 → XP_006229562.1  AN1-type zinc finger protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006229562.1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    18. XM_006229502.5 → XP_006229564.1  AN1-type zinc finger protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006229564.1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    19. XM_063284842.1 → XP_063140912.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8E7, A6JCP2

    20. XM_006229504.4 → XP_006229566.1  AN1-type zinc finger protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006229566.1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    21. XM_039105745.2 → XP_038961673.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    22. XM_063284851.1 → XP_063140921.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8E7, A6JCP2

    23. XM_063284809.1 → XP_063140879.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q6DGF4
      UniProtKB/TrEMBL
      A0A8I5YCN4, A6JCP3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DGF4.1 GenPept UniProtKB/Swiss-Prot:Q6DGF4

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