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    Myl4 myosin, light chain 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myl4provided by RGD
    Official Full Name
    myosin, light chain 4provided by RGD
    Primary source
    RGD:1591197
    See related
    EnsemblRapid:ENSRNOG00000050675 AllianceGenome:RGD:1591197
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in cardiac muscle contraction; positive regulation of ATP-dependent activity; and regulation of the force of heart contraction. Predicted to be part of myosin II complex. Predicted to be active in A band. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1417.0), Lung (RPKM 199.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myl4 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89949733..89985308)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (89449456..89485365)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (92628356..92638100)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene uncharacterized LOC134480887 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene cell division cycle 27 Neighboring gene glutathione S-transferase pi 1, pseudogene 2 Neighboring gene integrin subunit beta 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation. Zhong Y, et al. Redox Biol, 2023 Apr. PMID 36645977, Free PMC Article
    2. Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats. Peng W, et al. J Am Heart Assoc, 2017 Oct 28. PMID 29080865, Free PMC Article
    3. Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model. Abdelaziz AI, et al. J Mol Med (Berl), 2004 Apr. PMID 14985854
    4. The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function. Timson DJ, et al. Eur J Biochem, 1998 Aug 1. PMID 9738905
    5. Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension. Rovner AS, et al. Nucleic Acids Res, 1990 Mar 25. PMID 2326197, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation.
      Title: Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation.
    2. Loss-of-function MYL4 gene variants cause progressive atrial cardiomyopathy in genetically modified rats.
      Title: Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in A band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin light chain 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109495.1 → NP_001102965.1  myosin light chain 4

      See identical proteins and their annotated locations for NP_001102965.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I5YBR7, A6HJW5, M0R4E1
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      89949733..89985308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086843.2 → XP_038942771.1  myosin light chain 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBR7, A6HJW5, M0R4E1
      Related
      ENSRNOP00000064224.1, ENSRNOT00000072480.3
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    2. XM_039086842.2 → XP_038942770.1  myosin light chain 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBR7, A6HJW5, M0R4E1
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    3. XM_039086841.2 → XP_038942769.1  myosin light chain 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBR7, A6HJW5, M0R4E1
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    4. XM_039086844.2 → XP_038942772.1  myosin light chain 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBR7, A6HJW5, M0R4E1
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17209.2 GenPept UniProtKB/Swiss-Prot:P17209

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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