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Pten phosphatase and tensin homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 50557, updated on 9-Dec-2024

Summary

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Official Symbol: Ptenprovided by RGD
Official Full Name: phosphatase and tensin homologprovided by RGD
Primary source: RGD:61995
See related: EnsemblRapid:ENSRNOG00000020723 AllianceGenome:RGD:61995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mmac; TEP1; MMAC1
Summary: Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; dephosphorylation; and negative regulation of developmental growth. Located in dendritic spine and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; glucose metabolism disease (multiple); liver disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 635.2), Lung (RPKM 588.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Pten in Genome Data Viewer

Location:: 1q52

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (240043707..240110330)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (230630443..230697070)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (251421814..251487634)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA XIST regulates osteoclast formation and promotes orthodontically induced inflammatory root resorption through miR-130b-3p/PTEN axis.
Title: LncRNA XIST regulates osteoclast formation and promotes orthodontically induced inflammatory root resorption through miR-130b-3p/PTEN axis.
Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury.
Title: Oxidized DJ-1 activates the p-IKK/NF-κB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury.
Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPalpha signaling pathway.
Title: Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway.
N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.
Title: N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.
miR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting PTEN and Activating the PI3K/AKT Signaling Pathway.
Title: miR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting PTEN and Activating the PI3K/AKT Signaling Pathway.
Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events.
Title: Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events.
miR-181a targets PTEN to mediate the neuronal injury caused by oxygen-glucose deprivation and reoxygenation.
Title: miR-181a targets PTEN to mediate the neuronal injury caused by oxygen-glucose deprivation and reoxygenation.
Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage.
Title: Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage.
LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A.
Title: LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A.
miR-132-3p participates in the pathological mechanism of temporomandibular joint osteoarthritis by targeting PTEN.
Title: miR-132-3p participates in the pathological mechanism of temporomandibular joint osteoarthritis by targeting PTEN.

Submit: New GeneRIF Correction See all GeneRIFs (176)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pten (e-PCR), detects polymorphism
- UniSTS:144288

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables anaphase-promoting complex binding	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin ligase activator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in brain morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to decreased oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin-like growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to leptin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to sorbitol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dentate gyrus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in forebrain morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in inositol phosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in male mating behavior	ISO Inferred from Sequence Orthology more info
involved_in maternal behavior	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ribosome biogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron-neuron synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular component size	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of macrophage apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to ATP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in rhythmic synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly involved in female meiosis	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in myelin sheath adaxonal region	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Names: inositol polyphosphate 3-phosphatase; mutated in multiple advanced cancers 1; phosphatase and tensin homolog deleted on chromosome ten; protein tyrosine phosphatase and tensin-like protein

NP_113794.1

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.67

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031606.2 → NP_113794.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

See identical proteins and their annotated locations for NP_113794.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O54857

UniProtKB/TrEMBL

A6I112

Related

ENSRNOP00000097310.1, ENSRNOT00000117228.2

Conserved Domains (2) summary

cd14509
Location:24 → 181

PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog

pfam10409
Location:188 → 349

PTEN_C2; C2 domain of PTEN tumor-suppressor protein