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    Apoa5 apolipoprotein A5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140638, updated on 4-Jan-2025

    Summary

    Official Symbol
    Apoa5provided by RGD
    Official Full Name
    apolipoprotein A5provided by RGD
    Primary source
    RGD:70903
    See related
    EnsemblRapid:ENSRNOG00000018436 AllianceGenome:RGD:70903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    apo-AV; apoA-V
    Summary
    Predicted to enable several functions, including cholesterol transfer activity; enzyme activator activity; and heparin binding activity. Involved in animal organ regeneration; lipid transport; and response to hormone. Located in extracellular space. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in cerebral infarction; coronary artery disease; familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to human APOA5 (apolipoprotein A5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 2621.3) See more
    Orthologs
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    Genomic context

    See Apoa5 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55446329..55460509)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46561180..46563818)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50559079..50561720)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein C3 Neighboring gene apolipoprotein A4 Neighboring gene ZPR1 zinc finger Neighboring gene uncharacterized LOC134480162 Neighboring gene BUD13 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC108612

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol transfer activity  
    enables enzyme activator activity  
    enables enzyme binding  
    enables heparin binding  
    enables heparin binding  
    enables lipase activator activity  
    enables lipase binding  
    enables lipase binding  
    enables lipid binding  
    enables lipid binding  
    enables lipoprotein lipase activator activity  
    enables lipoprotein lipase activator activity  
    enables lipoprotein particle receptor binding  
    enables low-density lipoprotein particle receptor binding  
    enables low-density lipoprotein particle receptor binding  
    enables phosphatidylcholine binding  
    enables phosphatidylcholine binding  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phospholipid binding  
    enables phospholipid binding  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in acylglycerol homeostasis  
    involved_in acylglycerol homeostasis  
    involved_in animal organ regeneration PubMed 
    involved_in cholesterol efflux  
    involved_in cholesterol homeostasis  
    involved_in cholesterol homeostasis  
    involved_in cholesterol metabolic process  
    involved_in lipid transport  
    involved_in lipid transport PubMed 
    involved_in lipid transport  
    involved_in lipoprotein metabolic process  
    involved_in phospholipid efflux  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in positive regulation of lipid catabolic process  
    involved_in positive regulation of lipoprotein lipase activity  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in positive regulation of very-low-density lipoprotein particle remodeling  
    involved_in positive regulation of very-low-density lipoprotein particle remodeling  
    involved_in response to hormone PubMed 
    involved_in tissue regeneration  
    involved_in tissue regeneration  
    involved_in triglyceride catabolic process  
    involved_in triglyceride catabolic process  
    involved_in triglyceride homeostasis  
    involved_in triglyceride homeostasis  
    acts_upstream_of_or_within triglyceride metabolic process  
    involved_in triglyceride metabolic process  
    involved_in triglyceride-rich lipoprotein particle remodeling  
    acts_upstream_of_or_within triglyceride-rich lipoprotein particle remodeling  
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    part_of chylomicron  
    part_of chylomicron  
    part_of chylomicron  
    located_in early endosome  
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular vesicle  
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle  
    located_in late endosome  
    NOT part_of low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  

    General protein information

    Preferred Names
    apolipoprotein A-V
    Names
    regeneration-associated protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277264.1NP_001264193.1  apolipoprotein A-V precursor

      See identical proteins and their annotated locations for NP_001264193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC089780, JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5FVT8, Q9QUH3
      UniProtKB/TrEMBL
      A0A8I6ASM1
      Related
      ENSRNOP00000094966.2, ENSRNOT00000102490.2
      Conserved Domains (1) summary
      pfam01442
      Location:65242
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    2. NM_080576.2NP_542143.1  apolipoprotein A-V precursor

      See identical proteins and their annotated locations for NP_542143.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC089780
      UniProtKB/Swiss-Prot
      Q5FVT8, Q9QUH3
      UniProtKB/TrEMBL
      A0A8I6ASM1
      Related
      ENSRNOP00000024918.4, ENSRNOT00000024918.7
      Conserved Domains (1) summary
      pfam01442
      Location:65242
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55446329..55460509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264800.1XP_063120870.1  apolipoprotein A-V isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHP7, A6J475
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