Fez1 fasciculation and elongation protein zeta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fez1provided by RGD
Official Full Name: fasciculation and elongation protein zeta 1provided by RGD
Primary source: RGD:619708
See related: EnsemblRapid:ENSRNOG00000006075 AllianceGenome:RGD:619708
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein kinase C binding activity. Involved in several processes, including hippocampus development; positive regulation of anterograde axonal transport of mitochondrion; and positive regulation of neuron projection development. Located in dendrite; growth cone; and neuronal cell body. Biomarker of Parkinson's disease. Orthologous to human FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 1106.9) and Uterus (RPKM 45.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (44733288..44778519)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (36544462..36589684)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (39305128..39350270)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
Title: Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development.
Title: FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development.
Results indicate that astrocytic FEZ1 and glutamate-glutamine cycle dysfunction may be involved in the pathogenesis of depression after frontal lobe injury.
Title: Fasciculation and Elongation Protein Zeta-1 Expression in Reactive Astrocytes in a Rat Model of Frontal Lobe Injury.
Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking.
Title: Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1
Title: The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection.
Immunocytochemistry revealed that FEZ1 was located in the astrocytic cytoplasm and cell processes but not the nucleus
Title: Expression of fasciculation and elongation protein zeta-1 (FEZ1) in cultured rat neonatal astrocytes.
the FEZ1/kinesin complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells.
Title: Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells.
Therefore, our results strongly suggest that FEZ1 participates in the establishment of neuronal polarity by controlling the mitochondrial motility along axon.
Title: Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility.
E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation
Title: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells.
Title: Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Rat218 (e-PCR), detects polymorphism
- UniSTS:119113

D11S3963E (e-PCR)
- UniSTS:153775

D8Rat220 (e-PCR), detects polymorphism
- UniSTS:228285

AU025773 (e-PCR)
- UniSTS:114934

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of anterograde axonal transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fasciculation and elongation protein zeta-1

Names: protein kinase C-binding protein Zeta1; zygin I; zygin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031066.1 → NP_112328.1 fasciculation and elongation protein zeta-1

See identical proteins and their annotated locations for NP_112328.1

Status: PROVISIONAL

Source sequence(s)

U63740

UniProtKB/Swiss-Prot

P97577, Q62922

UniProtKB/TrEMBL

A6KRM5

Related

ENSRNOP00000008285.4, ENSRNOT00000008285.5

Conserved Domains (1) summary

pfam07763
Location:58 → 298

FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

44733288..44778519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266208.1 → XP_063122278.1 fasciculation and elongation protein zeta-1 isoform X1
XM_063266210.1 → XP_063122280.1 fasciculation and elongation protein zeta-1 isoform X3
XM_063266209.1 → XP_063122279.1 fasciculation and elongation protein zeta-1 isoform X1
XM_039082202.2 → XP_038938130.1 fasciculation and elongation protein zeta-1 isoform X2

UniProtKB/Swiss-Prot

P97577, Q62922

UniProtKB/TrEMBL

A6KRM5

Related

ENSRNOP00000101366.1, ENSRNOT00000129566.1

Conserved Domains (1) summary

pfam07763
Location:58 → 298

FEZ; FEZ-like protein