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    Slc25a13 solute carrier family 25 member 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362322, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc25a13provided by RGD
    Official Full Name
    solute carrier family 25 member 13provided by RGD
    Primary source
    RGD:1565889
    See related
    EnsemblRapid:ENSRNOG00000009957 AllianceGenome:RGD:1565889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565889
    Summary
    Predicted to enable amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Predicted to be involved in several processes, including ATP biosynthetic process; L-glutamate transmembrane transport; and gluconeogenesis. Predicted to act upstream of or within aspartate transmembrane transport and malate-aspartate shuttle. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in adult-onset type II citrullinemia and neonatal-onset type II citrullinemia. Orthologous to human SLC25A13 (solute carrier family 25 member 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 935.8), Kidney (RPKM 448.5) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc25a13 in Genome Data Viewer
    Location:
    4q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (35145721..35328403, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (34179224..34361912, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (31134165..31757006, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29, pseudogene 20 Neighboring gene dynein cytoplasmic 1 intermediate chain 1 Neighboring gene U6 spliceosomal RNA Neighboring gene protein LLP homolog pseudogene Neighboring gene ribosomal protein L31 like 14 Neighboring gene uncharacterized LOC102554854 Neighboring gene uncharacterized LOC103692052

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-sulfino-L-alanine: proton, glutamate antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3-sulfino-L-alanine: proton, glutamate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3-sulfino-L-alanine: proton, glutamate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables L-aspartate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-glutamate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acidic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aspartate:glutamate, proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aspartate:glutamate, proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aspartate:glutamate, proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cellular respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malate-aspartate shuttle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in malate-aspartate shuttle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within malate-aspartate shuttle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malate-aspartate shuttle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutral amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
    Names
    calcium-binding mitochondrial carrier protein Aralar2
    solute carrier family 25 (aspartate/glutamate carrier), member 13
    solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
    solute carrier family 25, member 13 (citrin)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419624.1NP_001406553.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      F1LZW6
      Related
      ENSRNOP00000076742.2, ENSRNOT00000115980.2
    2. NM_001419627.1NP_001406556.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZK53
      Related
      ENSRNOP00000107914.1, ENSRNOT00000146991.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      35145721..35328403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108599.2XP_038964527.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A972
      Related
      ENSRNOP00000089641.1, ENSRNOT00000119208.2
      Conserved Domains (1) summary
      pfam00153
      Location:192284
      Mito_carr; Mitochondrial carrier protein
    2. XM_039108600.1XP_038964528.1  electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A972
      Conserved Domains (1) summary
      pfam00153
      Location:192284
      Mito_carr; Mitochondrial carrier protein

    RNA

    1. XR_005503443.2 RNA Sequence

    2. XR_005503442.2 RNA Sequence

      Related
      ENSRNOT00000013817.9