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    Bzw2 basic leucine zipper and W2 domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171439, updated on 27-Nov-2024

    Summary

    Official Symbol
    Bzw2provided by RGD
    Official Full Name
    basic leucine zipper and W2 domains 2provided by RGD
    Primary source
    RGD:621507
    See related
    EnsemblRapid:ENSRNOG00000005096 AllianceGenome:RGD:621507
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hfb2
    Summary
    Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 1249.2), Muscle (RPKM 393.6) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bzw2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (58555362..58615921, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (52828069..52888599, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (55586754..55647650, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 13 Neighboring gene uncharacterized LOC134479367 Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 3 Neighboring gene leucine rich repeat containing 72 Neighboring gene MYC associated factor X, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    eIF5-mimic protein 1
    Names
    basic leucine zipper and W2 domain-containing protein 2
    brain development-related molecule 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134402.3NP_599229.1  eIF5-mimic protein 1

      See identical proteins and their annotated locations for NP_599229.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063149
      UniProtKB/Swiss-Prot
      Q9WTT7
      UniProtKB/TrEMBL
      A0A8I5ZSL9, A6HBA9
      Related
      ENSRNOP00000007414.2, ENSRNOT00000007414.5
      Conserved Domains (1) summary
      cd11560
      Location:218408
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      58555362..58615921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261524.1XP_063117594.1  eIF5-mimic protein 1 isoform X1

    2. XM_063261525.1XP_063117595.1  eIF5-mimic protein 1 isoform X2