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    Pdk4 pyruvate dehydrogenase kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89813, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pdk4provided by RGD
    Official Full Name
    pyruvate dehydrogenase kinase 4provided by RGD
    Primary source
    RGD:69061
    See related
    EnsemblRapid:ENSRNOG00000009565 AllianceGenome:RGD:69061
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in protein phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 473.1), Heart (RPKM 258.8) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pdk4 in Genome Data Viewer
    Location:
    4q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (34558327..34568329, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (33591796..33601798, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (30546772..30556774, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552448 Neighboring gene villin 1, pseudogene 1 Neighboring gene ribosomal protein S29, pseudogene 20 Neighboring gene dynein cytoplasmic 1 intermediate chain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ketone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of pH ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    pyruvate dehydrogenase kinase, isozyme 4
    Names
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
    pyruvate dehydrogenase kinase, isoenzyme 4
    pyruvate dehydrogenate kinase 4
    NP_446003.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053551.2NP_446003.2  pyruvate dehydrogenase kinase, isozyme 4

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      O54937
      UniProtKB/TrEMBL
      A6IDT8, G3V778
      Related
      ENSRNOP00000012759.1, ENSRNOT00000012760.6
      Conserved Domains (2) summary
      cd16929
      Location:199365
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
      pfam10436
      Location:34195
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      34558327..34568329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)