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Vegfa vascular endothelial growth factor A [ Mus musculus (house mouse) ]

Gene ID: 22339, updated on 27-Nov-2024

Summary

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Official Symbol: Vegfaprovided by MGI
Official Full Name: vascular endothelial growth factor Aprovided by MGI
Primary source: MGI:MGI:103178
See related: Ensembl:ENSMUSG00000023951 AllianceGenome:MGI:103178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vpf; Vegf; L-VEGF
Summary: This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]
Expression: Broad expression in lung adult (RPKM 187.9), adrenal adult (RPKM 89.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

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See Vegfa in Genome Data Viewer

Location:: 17 C; 17 22.79 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46327919..46343303, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46016993..46032377, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF20-mediated transcriptional pausing and VEGFA splicing orchestrate vessel growth.
Title: RNF20-mediated transcriptional pausing and VEGFA splicing orchestrate vessel growth.
Hepatic-derived BMP9 is involved in hepatic fibrosis-induced kidney injury through inhibition of renal VEGFA.
Title: Hepatic-derived BMP9 is involved in hepatic fibrosis-induced kidney injury through inhibition of renal VEGFA.
Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell.
Title: Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell.
VEGF expression disparities in brainstem motor neurons of the SOD1[G93A] ALS model: Correlations with neuronal vulnerability.
Title: VEGF expression disparities in brainstem motor neurons of the SOD1(G93A) ALS model: Correlations with neuronal vulnerability.
AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling.
Title: AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling.
Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.
Title: Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.
Suppression of mir-150-5p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis.
Title: Suppression of mir-150-5p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis.
GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
Title: GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression.
Title: Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression.
VEGF and Neuronal Survival.
Title: VEGF and Neuronal Survival.

Submit: New GeneRIF Correction See all GeneRIFs (1005)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Vegfa (e-PCR), detects polymorphism
- UniSTS:546056

Vegfa (e-PCR), detects polymorphism
- UniSTS:471318

Vegfa (e-PCR), detects polymorphism
- UniSTS:462632

Vegfa (e-PCR), detects polymorphism
- UniSTS:498728

PMC20712P1 (e-PCR)
- UniSTS:271944

PMC20712P2 (e-PCR)
- UniSTS:271945

Vegfa (e-PCR), detects polymorphism
- UniSTS:545873

NoName (e-PCR)
- UniSTS:548179

Vegfa (e-PCR), detects polymorphism
- UniSTS:516695

Vegfa (e-PCR), detects polymorphism
- UniSTS:463960

Vegfa (e-PCR), detects polymorphism
- UniSTS:280408

Vegfa (e-PCR), detects polymorphism
- UniSTS:280409

VEGF_1127 (e-PCR)
- UniSTS:277860

VEGF_V308 (e-PCR)
- UniSTS:277860

Vegf (e-PCR), detects polymorphism
- UniSTS:144751

Vegf (e-PCR), detects polymorphism
- UniSTS:144752

Vegf (e-PCR), detects polymorphism
- UniSTS:144753

Vegf (e-PCR), detects polymorphism
- UniSTS:181877

Vegf (e-PCR), detects polymorphism
- UniSTS:181878

Vegfa (e-PCR), detects polymorphism
- UniSTS:530594

D2Wox60 (e-PCR)
- UniSTS:240057

PMC262691P3 (e-PCR)
- UniSTS:272325

Vegfa (e-PCR), detects polymorphism
- UniSTS:496838

Vegf (e-PCR), detects polymorphism
- UniSTS:166627

Vegfa (e-PCR), detects polymorphism
- UniSTS:528636

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neuropilin binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane receptor protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 1 binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 1 binding	ISS Inferred from Sequence or Structural Similarity more info
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 2 binding	ISS Inferred from Sequence or Structural Similarity more info
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in VEGF-activated neuropilin signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in VEGF-activated neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in VEGF-activated neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis involved in coronary vascular morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone trabecula morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac vascular smooth muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to vascular endothelial growth factor stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular stress response to acid chemical	IEA Inferred from Electronic Annotation more info
involved_in cellular stress response to acid chemical	ISO Inferred from Sequence Orthology more info
NOT involved_in commissural neuron axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in commissural neuron axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coronary artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coronary vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of lymphangiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adherens junction organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of blood-brain barrier permeability	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in positive regulation of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lymphangiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of trophoblast cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of vascular permeability	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in retinal ganglion cell axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tube formation	ISO Inferred from Sequence Orthology more info
involved_in tube formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor-2 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular wound healing	IEA Inferred from Electronic Annotation more info
involved_in vascular wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of VEGF-A complex	IEA Inferred from Electronic Annotation more info
part_of VEGF-A complex	ISO Inferred from Sequence Orthology more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vascular endothelial growth factor A, long form

Names: vascular permeability factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025250.3 → NP_001020421.2 vascular endothelial growth factor A, long form isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (1) represented in this RefSeq is translated from the CUG start codon and is the longest isoform.

Source sequence(s)

AK031905, BC061468, BQ554097, BY001490, CK626177

Consensus CDS

CCDS28816.2

UniProtKB/Swiss-Prot

F8WH81, O70123, Q00731, Q66S31, Q6GT23, Q6WZL9

UniProtKB/TrEMBL

F8WH10

Related

ENSMUSP00000115883.3, ENSMUST00000142351.9

Conserved Domains (2) summary

smart00141
Location:227 → 309

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:343 → 392

VEGF_C; VEGF heparin-binding domain
NM_001025257.3 → NP_001020428.2 vascular endothelial growth factor A, long form isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two consecutive in-frame coding exons, compared to variant 1. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (3) represented in this RefSeq is translated from the CUG start codon and it lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK031905, BC061468, BY001490, CK626177

Consensus CDS

CCDS28817.2

UniProtKB/TrEMBL

F8WH10

Conserved Domains (1) summary

smart00141
Location:227 → 309

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001110266.1 → NP_001103736.1 vascular endothelial growth factor A, long form isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (4) has a distinct and shorter N-terminus, compared to isoform 1. This variant has transcript support, but the protein is predicted.

Source sequence(s)

AC127690, AK031905, BC061468, BQ554097, BU920197

UniProtKB/Swiss-Prot

Q00731

Conserved Domains (2) summary

pfam14554
Location:89 → 137

VEGF_C; VEGF heparin-binding domain

cl00116
Location:27 → 54

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001110267.1 → NP_001103737.1 vascular endothelial growth factor A, long form isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and also lacks an in-frame, internal coding exon, compared to variant 1. The resulting isoform (5) has a distinct and shorter N-terminus and also lacks an internal segment, compared to isoform 1. This variant has transcript support, but the protein is predicted.

Source sequence(s)

AC127690, AK031905, BC061468, BQ554097, BU920197

UniProtKB/Swiss-Prot

Q00731

Conserved Domains (2) summary

pfam14554
Location:60 → 113

VEGF_C; VEGF heparin-binding domain

cl00116
Location:27 → 54

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001110268.1 → NP_001103738.1 vascular endothelial growth factor A, long form isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region and also lacks two consecutive in-frame, internal coding exons, compared to variant 1. The resulting isoform (6) has a distinct and shorter N-terminus and also lacks an internal segment, compared to isoform 1. This variant has transcript support, but the protein is predicted.

Source sequence(s)

AC127690, AK031905, BC061468, BQ554097, BU920197

UniProtKB/Swiss-Prot

Q00731

Conserved Domains (1) summary

cl00116
Location:27 → 54

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001287056.1 → NP_001273985.1 vascular endothelial growth factor A, long form isoform 7 precursor

See identical proteins and their annotated locations for NP_001273985.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG. The isoform (7) represented in this RefSeq is translated from the AUG start codon and is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AK031905, BC061468, BQ554097, BY001490, CK626177

UniProtKB/TrEMBL

E9Q4N8

Related

ENSMUSP00000109148.2, ENSMUST00000113520.8

Conserved Domains (2) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:166 → 214

VEGF_C; VEGF heparin-binding domain
NM_001287057.1 → NP_001273986.1 vascular endothelial growth factor A, long form isoform Vegf-A precursor

See identical proteins and their annotated locations for NP_001273986.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal, in-frame coding exon compared to variant 1. It can initiate translation from a non-AUG (CUG) codon, and also from an in-frame, downstream AUG start codon. The isoform (Vegf-A) represented in this RefSeq is derived from the AUG start codon. It has a shorter N-terminus and lacks an internal protein segment compared to isoform 1. This variant also encodes a C-terminally extended isoform (Vegf-Ax), which results from the use of an alternative in-frame, downstream translation termination codon (UAA). Isoform Vegf-Ax is represented in NM_001317041.1.

Source sequence(s)

AK031905, BC061468, BY001490, CK626177

UniProtKB/TrEMBL

E9Q4N8

Conserved Domains (2) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:137 → 190

VEGF_C; VEGF heparin-binding domain
NM_001287058.1 → NP_001273987.1 vascular endothelial growth factor A, long form isoform 9 precursor

See identical proteins and their annotated locations for NP_001273987.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two consecutive in-frame coding exons, compared to variant 1. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (9) represented in this RefSeq is translated from the AUG start codon. It has a shorter N-terminus and also lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK031905, BC061468, BY001490, CK626177

Consensus CDS

CCDS70817.1

UniProtKB/TrEMBL

A0FKR4

Related

ENSMUSP00000024747.8, ENSMUST00000024747.14

Conserved Domains (1) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001317041.1 → NP_001303970.1 vascular endothelial growth factor A, long form isoform Vegf-Ax precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) is identical to NM_001287057.1; however, it uses an alternative in-frame, downstream translation termination codon (UAA), which results in a longer, C-terminally extended isoform (Vegf-Ax) compared to isoform Vegf-A. Unlike isoform Vegf-A, which is proangiogenic, Vegf-Ax exhibits antiangiogenic activity. As the upstream UGA stop codon has been shown to be recoded as serine (PMID:24949972), its location in the Vegf-Ax isoform (aa 191) is denoted by an 'S'.

Source sequence(s)

AK031905, BC061468, BY001490, CK626177

UniProtKB/TrEMBL

E9Q4N8

Conserved Domains (2) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:142 → 190

VEGF_C; VEGF heparin-binding domain
NM_009505.4 → NP_033531.3 vascular endothelial growth factor A, long form isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame, internal coding exon, compared to variant 1. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (2) represented in this RefSeq is translated from the CUG start codon and it lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK031905, BC061468, BY001490, CK626177

Consensus CDS

CCDS28818.2

UniProtKB/TrEMBL

F8WH10

Related

ENSMUSP00000071575.6, ENSMUST00000071648.12

Conserved Domains (2) summary

smart00141
Location:227 → 309

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:315 → 368

VEGF_C; VEGF heparin-binding domain