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    Heca hdc homolog, cell cycle regulator [ Mus musculus (house mouse) ]

    Gene ID: 380629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hecaprovided by MGI
    Official Full Name
    hdc homolog, cell cycle regulatorprovided by MGI
    Primary source
    MGI:MGI:2685715
    See related
    Ensembl:ENSMUSG00000039879 AllianceGenome:MGI:2685715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HDC; HDCL; Gm869
    Summary
    Predicted to be involved in negative regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human HECA (hdc homolog, cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.7), lung adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Heca in Genome Data Viewer
    Location:
    10 A3; 10 7.31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (17774788..17823785, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (17899040..17948067, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20655 Neighboring gene STARR-seq mESC enhancer starr_25884 Neighboring gene taxilin beta Neighboring gene chromodomain protein, Y chromosome-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_25885 Neighboring gene predicted gene, 57800 Neighboring gene STARR-seq mESC enhancer starr_25887 Neighboring gene STARR-positive B cell enhancer mm9_chr10:17667807-17668108 Neighboring gene STARR-positive B cell enhancer ABC_E5120 Neighboring gene ABRA C-terminal like Neighboring gene STARR-seq mESC enhancer starr_25888 Neighboring gene RalBP1 associated Eps domain containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    headcase protein homolog
    Names
    headcase homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033432.4 → NP_001028604.1  headcase protein homolog

      See identical proteins and their annotated locations for NP_001028604.1

      Status: VALIDATED

      Source sequence(s)
      AC153896
      Consensus CDS
      CCDS23709.1
      UniProtKB/TrEMBL
      Q3V1N5
      Related
      ENSMUSP00000040707.7, ENSMUST00000037879.8
      Conserved Domains (2) summary
      pfam15353
      Location:94 → 192
      HECA; Headcase protein family homologue
      pfam16002
      Location:344 → 535
      Headcase; Headcase protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      17774788..17823785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512783.5 → XP_006512846.1  headcase protein homolog isoform X1

      Conserved Domains (2) summary
      pfam15353
      Location:40 → 138
      HECA; Headcase protein family homolog
      pfam16002
      Location:286 → 481
      Headcase; Headcase protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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