Rsbn1 rosbin, round spermatid basic protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rsbn1provided by MGI
Official Full Name: rosbin, round spermatid basic protein 1provided by MGI
Primary source: MGI:MGI:2444993
See related: Ensembl:ENSMUSG00000044098 AllianceGenome:MGI:2444993
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KDM9; Rsbn; Rsbp; Rosbin; mKIAA3002; E330004N01; C230004D03Rik
Summary: Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in nucleus. Is expressed in metanephros; oviduct; testis; and thymus. Orthologous to human RSBN1 (round spermatid basic protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 6.9), whole brain E14.5 (RPKM 5.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.52 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (103821412..103873952)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (103914090..103966638)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative distributions of RSBN1 and methylated histone H4 Lysine 20 in the mouse spermatogenesis.
Title: Comparative distributions of RSBN1 and methylated histone H4 Lysine 20 in the mouse spermatogenesis.
MicroRNA378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells.
Title: MicroRNA‑378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells.
Rosbin is associated with and is most likely phosphorylated by protein kinase A. We suggest that it plays an important role in transcriptional regulation in haploid germ cells.
Title: Rosbin: a novel homeobox-like protein gene expressed exclusively in round spermatids.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H4K20 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysine-specific demethylase 9

Names: round spermatid basic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.