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    Ahcyl adenosylhomocysteinase like [ Mus musculus (house mouse) ]

    Gene ID: 11615, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ahcylprovided by MGI
    Official Full Name
    adenosylhomocysteinase likeprovided by MGI
    Primary source
    MGI:MGI:3643647
    See related
    Ensembl:ENSMUSG00000048087 AllianceGenome:MGI:3643647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4737; EG11615; AL024110
    Summary
    Predicted to enable NAD binding activity; adenosylhomocysteinase activity; and identical protein binding activity. Predicted to be involved in several processes, including S-adenosylhomocysteine catabolic process; chronic inflammatory response to antigenic stimulus; and circadian sleep/wake cycle. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See Ahcyl in Genome Data Viewer
    Location:
    16 B5; 16 30.45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45973348..45975440, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (46152985..46155077, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31198 Neighboring gene CD96 antigen Neighboring gene STARR-seq mESC enhancer starr_40924 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46104635-46104888 Neighboring gene zinc finger BED-type containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46120234-46120417 Neighboring gene predicted gene, 26297 Neighboring gene nectin cell adhesion molecule 3

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenosylhomocysteinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenyl nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chronic inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian sleep/wake cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304528.1NP_001291457.1  Adenosylhomocysteinase

      See identical proteins and their annotated locations for NP_001291457.1

      Status: VALIDATED

      Source sequence(s)
      AC139039
      Consensus CDS
      CCDS84240.1
      UniProtKB/Swiss-Prot
      P50247, Q91WF1
      UniProtKB/TrEMBL
      Q3TF14, Q3U4D1, Q5M9P0
      Related
      ENSMUSP00000127198.2, ENSMUST00000059524.7
      Conserved Domains (1) summary
      smart00996
      Location:8431
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45973348..45975440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_004757.4: Suppressed sequence

      Description
      NG_004757.4: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.