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    Ctps2 cytidine 5'-triphosphate synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 55936, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ctps2provided by MGI
    Official Full Name
    cytidine 5'-triphosphate synthase 2provided by MGI
    Primary source
    MGI:MGI:1933185
    See related
    Ensembl:ENSMUSG00000031360 AllianceGenome:MGI:1933185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctpsh; A830031M15Rik
    Summary
    Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in CTP biosynthetic process and pyrimidine nucleobase biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 5.8), cerebellum adult (RPKM 5.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctps2 in Genome Data Viewer
    Location:
    X F4; X 75.09 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (161684264..161817537)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (162901268..163034541)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11687 Neighboring gene synapse associated protein 1 Neighboring gene microRNA 3473a Neighboring gene predicted gene 15209 Neighboring gene Mki67 (FHA domain) interacting nucleolar phosphoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_48220 Neighboring gene STARR-seq mESC enhancer starr_48221 Neighboring gene STARR-seq mESC enhancer starr_48222 Neighboring gene S100 calcium binding protein G Neighboring gene STARR-seq mESC enhancer starr_48223 Neighboring gene STARR-seq mESC enhancer starr_48224 Neighboring gene STARR-seq mESC enhancer starr_48225 Neighboring gene predicted gene, 22746 Neighboring gene STARR-seq mESC enhancer starr_48226 Neighboring gene STARR-seq mESC enhancer starr_48227 Neighboring gene STARR-seq mESC enhancer starr_48228 Neighboring gene predicted gene 15212

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice. Soudais C, et al. Nat Commun, 2024 Mar 4. PMID 38438357, Free PMC Article
    2. CTPS and IMPDH form cytoophidia in developmental thymocytes. Peng M, et al. Exp Cell Res, 2021 Aug 1. PMID 34022203
    3. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoophidium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    CTP synthase 2
    Names
    CTP synthetase 2
    CTP synthetase homolog
    UTP--ammonia ligase 2
    cytidine triphosphate synthase II
    NP_001162040.1
    NP_001162041.1
    NP_001162043.1
    NP_001345327.1
    NP_061207.1
    XP_006528975.1
    XP_006528976.1
    XP_006528978.1
    XP_030107269.1
    XP_030107270.1
    XP_036017926.1
    XP_036017927.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168568.1 → NP_001162040.1  CTP synthase 2 isoform a

      See identical proteins and their annotated locations for NP_001162040.1

      Status: VALIDATED

      Source sequence(s)
      AK084595, AL671975, AW048867, BY288253
      Consensus CDS
      CCDS41202.1
      UniProtKB/Swiss-Prot
      P70303, Q3TPQ2, Q3TT59
      Related
      ENSMUSP00000033727.8, ENSMUST00000033727.14
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase

    2. NM_001168569.1 → NP_001162041.1  CTP synthase 2 isoform a

      See identical proteins and their annotated locations for NP_001162041.1

      Status: VALIDATED

      Source sequence(s)
      AK052854, AL671975, AW048867, BY314159
      Consensus CDS
      CCDS41202.1
      UniProtKB/Swiss-Prot
      P70303, Q3TPQ2, Q3TT59
      Related
      ENSMUSP00000107922.2, ENSMUST00000112303.8
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase

    3. NM_001168571.1 → NP_001162043.1  CTP synthase 2 isoform b

      See identical proteins and their annotated locations for NP_001162043.1

      Status: VALIDATED

      Source sequence(s)
      AK164206, AL671975, AW048867, BY098422, BY314159
      Consensus CDS
      CCDS53240.1
      UniProtKB/Swiss-Prot
      P70303
      Related
      ENSMUSP00000107921.2, ENSMUST00000112302.8
      Conserved Domains (3) summary
      cd01746
      Location:299 → 493
      GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
      PLN02327
      Location:1 → 506
      PLN02327; CTP synthase
      pfam06418
      Location:2 → 272
      CTP_synth_N; CTP synthase N-terminus

    4. NM_001358398.1 → NP_001345327.1  CTP synthase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL671975, AL807822, AW048867
      Conserved Domains (1) summary
      PLN02327
      Location:50 → 606
      PLN02327; CTP synthase

    5. NM_018737.5 → NP_061207.1  CTP synthase 2 isoform a

      See identical proteins and their annotated locations for NP_061207.1

      Status: VALIDATED

      Source sequence(s)
      AK150966, AL671975, AW048867, BY098422, BY314159
      Consensus CDS
      CCDS41202.1
      UniProtKB/Swiss-Prot
      P70303, Q3TPQ2, Q3TT59
      Related
      ENSMUSP00000107920.2, ENSMUST00000112301.8
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase

    RNA

    1. NR_033143.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671975, AL807822, AW048867

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      161684264..161817537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528912.3 → XP_006528975.1  CTP synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_006528975.1

      UniProtKB/Swiss-Prot
      P70303, Q3TPQ2, Q3TT59
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase

    2. XM_006528913.3 → XP_006528976.1  CTP synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_006528976.1

      UniProtKB/Swiss-Prot
      P70303, Q3TPQ2, Q3TT59
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase

    3. XM_030251409.2 → XP_030107269.1  CTP synthase 2 isoform X2

      Conserved Domains (1) summary
      PLN02327
      Location:4 → 432
      PLN02327; CTP synthase

    4. XM_030251410.2 → XP_030107270.1  CTP synthase 2 isoform X3

      Conserved Domains (1) summary
      PLN02327
      Location:1 → 401
      PLN02327; CTP synthase

    5. XM_036162034.1 → XP_036017927.1  CTP synthase 2 isoform X3

      Conserved Domains (1) summary
      PLN02327
      Location:1 → 401
      PLN02327; CTP synthase

    6. XM_006528915.2 → XP_006528978.1  CTP synthase 2 isoform X2

      See identical proteins and their annotated locations for XP_006528978.1

      Conserved Domains (1) summary
      PLN02327
      Location:4 → 432
      PLN02327; CTP synthase

    7. XM_036162033.1 → XP_036017926.1  CTP synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      P70303, Q3TPQ2, Q3TT59
      Conserved Domains (1) summary
      PLN02327
      Location:1 → 557
      PLN02327; CTP synthase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70303.1 GenPept UniProtKB/Swiss-Prot:P70303

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