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    Slc19a2 solute carrier family 19 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289175, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc19a2provided by RGD
    Official Full Name
    solute carrier family 19 member 2provided by RGD
    Primary source
    RGD:1308611
    See related
    EnsemblRapid:ENSRNOG00000002839 AllianceGenome:RGD:1308611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in several processes, including pyridoxine transport; thiamine diphosphate biosynthetic process; and thiamine transport. Predicted to act upstream of or within thiamine transmembrane transport. Predicted to be active in plasma membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in diabetes mellitus; megaloblastic anemia; and thiamine-responsive megaloblastic anemia syndrome. Orthologous to human SLC19A2 (solute carrier family 19 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 394.6), Kidney (RPKM 92.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc19a2 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79135118..79149316)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76601975..76616175)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82552586..82566586)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene selectin P Neighboring gene uncharacterized LOC134481524 Neighboring gene coagulation factor V Neighboring gene coiled-coil domain containing 181 Neighboring gene basic leucine zipper nuclear factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate. Hosoya K, et al. Drug Metab Pharmacokinet, 2008. PMID 18762716
    2. Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Labay V, et al. Nat Genet, 1999 Jul. PMID 10391221
    3. Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53. Lo PK, et al. J Biol Chem, 2001 Oct 5. PMID 11481326
    4. Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. Nabokina SM, et al. Am J Physiol Gastrointest Liver Physiol, 2011 Nov. PMID 21836059, Free PMC Article
    5. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Bukhari FJ, et al. Nephrol Dial Transplant, 2011 Jul. PMID 21149507, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. involvement of RFC1 in the inner BRB transport of methyltetrahydrofolate.
      Title: Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124887

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables thiamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in pyridoxine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thiamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thiamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within thiamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thiamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thiamine transporter 1
    Names
    solute carrier family 19 (thiamine transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030024.2 → NP_001025195.1  thiamine transporter 1

      See identical proteins and their annotated locations for NP_001025195.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I5ZVN5, Q499Q0
      Related
      ENSRNOP00000083604.1, ENSRNOT00000119412.2
      Conserved Domains (1) summary
      pfam01770
      Location:28 → 459
      Folate_carrier; Reduced folate carrier

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      79135118..79149316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090492.2 → XP_038946420.1  thiamine transporter 1 isoform X1

      UniProtKB/TrEMBL
      A0A096MJE7
      Related
      ENSRNOP00000068102.2, ENSRNOT00000076722.4
      Conserved Domains (1) summary
      pfam01770
      Location:37 → 436
      Folate_carrier; Reduced folate carrier

    2. XM_039090493.2 → XP_038946421.1  thiamine transporter 1 isoform X2

      UniProtKB/TrEMBL
      F1LNC9
      Related
      ENSRNOP00000003817.6, ENSRNOT00000003817.7
      Conserved Domains (1) summary
      pfam01770
      Location:22 → 416
      Folate_carrier; Reduced folate carrier

    3. XM_039090494.2 → XP_038946422.1  thiamine transporter 1 isoform X3

      Conserved Domains (1) summary
      pfam01770
      Location:16 → 415
      Folate_carrier; Reduced folate carrier

    4. XM_039090495.2 → XP_038946423.1  thiamine transporter 1 isoform X4

      Related
      ENSRNOP00000076963.2, ENSRNOT00000076186.3
      Conserved Domains (1) summary
      pfam01770
      Location:5 → 395
      Folate_carrier; Reduced folate carrier

    5. XM_039090496.1 → XP_038946424.1  thiamine transporter 1 isoform X5

      Conserved Domains (1) summary
      pfam01770
      Location:1 → 346
      Folate_carrier; Reduced folate carrier
    Nucleotide Protein Strain
    Heading Accession and Version

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