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    Wdr89 WD repeat domain 89 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr89provided by RGD
    Official Full Name
    WD repeat domain 89provided by RGD
    Primary source
    RGD:1307393
    See related
    EnsemblRapid:ENSRNOG00000021628 AllianceGenome:RGD:1307393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307393
    Summary
    Predicted to act upstream of or within corpus callosum development and ventricular system development. Orthologous to human WDR89 (WD repeat domain 89). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 37.0), Spleen (RPKM 31.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr89 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (100086169..100117796, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (94350468..94382085, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (98599456..98631512, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit B', epsilon Neighboring gene uncharacterized LOC120093261 Neighboring gene uncharacterized LOC120103554 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like Neighboring gene sphingosine-1-phosphate phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108878

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in corpus callosum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within corpus callosum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 89

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014078.2 → NP_001014100.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_001014100.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5FVP5
      UniProtKB/TrEMBL
      A6HC80
      Conserved Domains (3) summary
      COG2319
      Location:42 → 367
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:74 → 112
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:40 → 348
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      100086169..100117796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240233.5 → XP_006240295.1  WD repeat-containing protein 89 isoform X2

      See identical proteins and their annotated locations for XP_006240295.1

      UniProtKB/TrEMBL
      A0A8L2Q2X8
      Related
      ENSRNOP00000006860.4, ENSRNOT00000006860.6
      Conserved Domains (3) summary
      COG2319
      Location:53 → 378
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:51 → 359
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006240235.5 → XP_006240297.5  WD repeat-containing protein 89 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVP5
      UniProtKB/TrEMBL
      A6HC80
      Related
      ENSRNOP00000108226.1, ENSRNOT00000168328.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVP5.1 GenPept UniProtKB/Swiss-Prot:Q5FVP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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