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    Nt5c 5', 3'-nucleotidase, cytosolic [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nt5cprovided by RGD
    Official Full Name
    5', 3'-nucleotidase, cytosolicprovided by RGD
    Primary source
    RGD:2321875
    See related
    AllianceGenome:RGD:2321875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Umph2
    Summary
    Predicted to enable IMP 5'-nucleotidase activity; identical protein binding activity; and pyrimidine nucleotide binding activity. Predicted to be involved in several processes, including allantoin metabolic process; dephosphorylation; and nucleoside monophosphate catabolic process. Predicted to act upstream of or within deoxyribonucleotide catabolic process. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytosol. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 264.3), Thymus (RPKM 193.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nt5c in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101238552..101240666, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100739591..100742276, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104052807..104054805, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tripartite motif protein 80 Neighboring gene solute carrier family 16 member 5 Neighboring gene armadillo repeat containing 7 Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene small nucleolar RNA SNORA19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic 5'(3')-nucleotidase from human placenta. Höglund L, et al. J Biol Chem, 1990 Apr 25. PMID 2157703
    2. Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells. Rampazzo C, et al. J Biol Chem, 2000 Feb 25. PMID 10681516
    3. Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs. Rampazzo C, et al. Gene, 2002 Jul 10. PMID 12234672
    4. Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Yasue M, et al. Cytogenet Cell Genet, 1991. PMID 1914521
    5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables IMP 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrimidine nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in allantoin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dGMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dTMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within deoxyribonucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine deoxyribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine deoxyribonucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    5'(3')-deoxyribonucleotidase, cytosolic type
    Names
    5,3-nucleotidase, cytosolic
    uridine 5-monophosphate phosphohydrolase 2
    NP_001258118.1
    XP_038940922.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271189.1 → NP_001258118.1  5'(3')-deoxyribonucleotidase, cytosolic type

      See identical proteins and their annotated locations for NP_001258118.1

      Status: VALIDATED

      Source sequence(s)
      FQ233678
      UniProtKB/TrEMBL
      A6HKN4
      Conserved Domains (1) summary
      cl21460
      Location:5 → 196
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101238552..101240666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084994.2 → XP_038940922.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform X1

      Conserved Domains (1) summary
      cl21460
      Location:66 → 150
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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