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    Msrb3 methionine sulfoxide reductase B3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msrb3provided by RGD
    Official Full Name
    methionine sulfoxide reductase B3provided by RGD
    Primary source
    RGD:1596851
    See related
    EnsemblRapid:ENSRNOG00000042668 AllianceGenome:RGD:1596851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Predicted to be involved in protein repair. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 317.7), Muscle (RPKM 288.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msrb3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (58188827..58311459, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (56260985..56426004, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (62850506..62972487, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479698 Neighboring gene uncharacterized LOC134479700 Neighboring gene serine/threonine/tyrosine interacting protein, pseudogene 1 Neighboring gene LEM domain containing 3 Neighboring gene uncharacterized LOC120093617 Neighboring gene uncharacterized LOC134479701 Neighboring gene Wnt inhibitory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Kim HY, et al. Biochem Biophys Res Commun, 2004 Aug 6. PMID 15249228
    2. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Kim HY, et al. Mol Biol Cell, 2004 Mar. PMID 14699060, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-methionine-(R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methionine-R-sulfoxide reductase B3
    NP_001385888.1
    XP_063120313.1
    XP_063120314.1
    XP_063120315.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398959.1 → NP_001385888.1  methionine-R-sulfoxide reductase B3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A7J1, A6IGY5
      Conserved Domains (1) summary
      PRK00222
      Location:35 → 171
      PRK00222; peptide-methionine (R)-S-oxide reductase MsrB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      58188827..58311459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264243.1 → XP_063120313.1  methionine-R-sulfoxide reductase B3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZ33
      Related
      ENSRNOP00000084360.1, ENSRNOT00000113440.2

    2. XM_063264244.1 → XP_063120314.1  methionine-R-sulfoxide reductase B3 isoform X2

    3. XM_063264245.1 → XP_063120315.1  methionine-R-sulfoxide reductase B3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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