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    Eml4 EMAP like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eml4provided by RGD
    Official Full Name
    EMAP like 4provided by RGD
    Primary source
    RGD:1304690
    See related
    EnsemblRapid:ENSRNOG00000030294 AllianceGenome:RGD:1304690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and microtubule binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore; microtubule cytoskeleton organization; and mitotic metaphase chromosome alignment. Predicted to act upstream of or within negative regulation of microtubule depolymerization. Predicted to be located in cytosol; microtubule cytoskeleton; and midbody. Predicted to colocalize with mitotic spindle. Orthologous to human EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 208.3), Spleen (RPKM 194.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eml4 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16972054..17087365, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11219545..11334824, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6618370..6674550)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093197 Neighboring gene uncharacterized LOC134479098 Neighboring gene cytochrome c oxidase subunit 7A2 like Neighboring gene tumor protein, translationally-controlled 1 pseudogene 10 Neighboring gene uncharacterized LOC102556624 Neighboring gene uncharacterized LOC134479100

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Echinoderm microtubule-associated protein like protein 4, a member of the echinoderm microtubule-associated protein family, stabilizes microtubules. Houtman SH, et al. Neuroscience, 2007 Feb 23. PMID 17196341
    2. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Cheng L, et al. J Mol Cell Cardiol, 2022 Aug. PMID 35659652
    3. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    echinoderm microtubule-associated protein-like 4
    Names
    echinoderm microtubule associated protein like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433946.1 → NP_001420875.1  echinoderm microtubule-associated protein-like 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K2Z0, A0A8I6ALM1

    2. NM_001433947.1 → NP_001420876.1  echinoderm microtubule-associated protein-like 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A8G5, A0A8I6ALM1

    3. NM_001433948.1 → NP_001420877.1  echinoderm microtubule-associated protein-like 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9N1, F1LT71

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      16972054..17087365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112153.2 → XP_038968081.1  echinoderm microtubule-associated protein-like 4 isoform X6

      UniProtKB/TrEMBL
      A6H9N0
      Related
      ENSRNOP00000076696.2, ENSRNOT00000118377.2
      Conserved Domains (4) summary
      sd00039
      Location:537 → 572
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:124 → 195
      HELP; HELP motif
      cd21950
      Location:6 → 64
      TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
      cl29593
      Location:401 → 762
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039112152.2 → XP_038968080.1  echinoderm microtubule-associated protein-like 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y0M9, A6H9N1
      Conserved Domains (4) summary
      sd00039
      Location:548 → 583
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:135 → 206
      HELP; HELP motif
      cd21950
      Location:6 → 64
      TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
      cl29593
      Location:412 → 773
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039112151.2 → XP_038968079.1  echinoderm microtubule-associated protein-like 4 isoform X4

      UniProtKB/TrEMBL
      A6H9N0
      Conserved Domains (4) summary
      sd00039
      Location:580 → 615
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:167 → 238
      HELP; HELP motif
      cd21950
      Location:6 → 64
      TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
      cl29593
      Location:444 → 805
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_039112150.2 → XP_038968078.1  echinoderm microtubule-associated protein-like 4 isoform X3

      Related
      ENSRNOP00000050319.4, ENSRNOT00000042307.6
      Conserved Domains (4) summary
      sd00039
      Location:591 → 626
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:178 → 249
      HELP; HELP motif
      cd21950
      Location:6 → 64
      TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
      cl29593
      Location:455 → 816
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_039112149.2 → XP_038968077.1  echinoderm microtubule-associated protein-like 4 isoform X2

      Related
      ENSRNOP00000087686.1, ENSRNOT00000116346.2
      Conserved Domains (4) summary
      sd00039
      Location:638 → 673
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:225 → 296
      HELP; HELP motif
      cd21950
      Location:6 → 64
      TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
      cl29593
      Location:502 → 863
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_039112148.2 → XP_038968076.1  echinoderm microtubule-associated protein-like 4 isoform X1

      Related
      ENSRNOP00000072435.2, ENSRNOT00000080013.3
      Conserved Domains (4) summary
      sd00039
      Location:649 → 684
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:236 → 307
      HELP; HELP motif
      cd21950
      Location:6 → 64
      TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4
      cl29593
      Location:513 → 874
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_039112154.2 → XP_038968082.1  echinoderm microtubule-associated protein-like 4 isoform X7

      Conserved Domains (2) summary
      sd00039
      Location:315 → 350
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:179 → 540
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108008.1: Suppressed sequence

      Description
      NM_001108008.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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