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    LINC01094 long intergenic non-protein coding RNA 1094 [ Homo sapiens (human) ]

    Gene ID: 100505702, updated on 13-Nov-2024

    Summary

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    Official Symbol
    LINC01094provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1094provided by HGNC
    Primary source
    HGNC:HGNC:49219
    See related
    AllianceGenome:HGNC:49219
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTEPHA1
    Expression
    Biased expression in brain (RPKM 6.2), placenta (RPKM 2.2) and 7 other tissues See more
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    Genomic context

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    See LINC01094 in Genome Data Viewer
    Location:
    4q21.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (78645994..78684501)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (81981571..82020092)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (79567148..79605655)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21646 Neighboring gene small nucleolar RNA U13 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:79566785-79567984 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 13 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1973 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1974 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:79627314-79627946 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr4:79635971-79636917 Neighboring gene uncharacterized LOC101928893 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:79639668-79640239 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:79640240-79640810 Neighboring gene Sharpr-MPRA regulatory region 1360 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1978 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:79643097-79643668 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21651 Neighboring gene ribosomal protein S21 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Upregulated long intergenic non-protein coding RNA 1094 (LINC01094) is linked to poor prognosis and alteration of cell function in colorectal cancer. Zhang G, et al. Bioengineered, 2022 Apr. PMID 35287563, Free PMC Article
    2. LINC01094 Predicts Poor Prognosis in Patients With Gastric Cancer and is Correlated With EMT and Macrophage Infiltration. Ye Y, et al. Technol Cancer Res Treat, 2022 Jan-Dec. PMID 35254147, Free PMC Article
    3. miRNA-PDGFRB/HIF1A-lncRNA CTEPHA1 Network Plays Important Roles in the Mechanism of Chronic Thromboembolic Pulmonary Hypertension. Wang M, et al. Int Heart J, 2019 Jul 27. PMID 31204374
    4. LINC01094 promotes human nasal epithelial cell epithelial-to-mesenchymal transition and pyroptosis via upregulating HMGB1. Liu Z, et al. Rhinology, 2024 Feb 1. PMID 37864411
    5. Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis. Huang F, et al. J Orthop Surg (Hong Kong), 2024 May-Aug. PMID 38758016

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis.
      Title: Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis.
    2. LINC01094 promotes human nasal epithelial cell epithelial-to-mesenchymal transition and pyroptosis via upregulating HMGB1.
      Title: LINC01094 promotes human nasal epithelial cell epithelial-to-mesenchymal transition and pyroptosis via upregulating HMGB1.
    3. LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis.
      Title: LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis.
    4. LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination.
      Title: LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination.
    5. Upregulated long intergenic non-protein coding RNA 1094 (LINC01094) is linked to poor prognosis and alteration of cell function in colorectal cancer.
      Title: Upregulated long intergenic non-protein coding RNA 1094 (LINC01094) is linked to poor prognosis and alteration of cell function in colorectal cancer.
    6. LINC01094 Predicts Poor Prognosis in Patients With Gastric Cancer and is Correlated With EMT and Macrophage Infiltration.
      Title: LINC01094 Predicts Poor Prognosis in Patients With Gastric Cancer and is Correlated With EMT and Macrophage Infiltration.
    7. Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis.
      Title: Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis.
    8. LncRNA LINC01094 contributes to glioma progression by modulating miR-224-5p/CHSY1 axis.
      Title: LncRNA LINC01094 contributes to glioma progression by modulating miR-224-5p/CHSY1 axis.
    9. Upregulation of LINC01094 was confirmed in Clear cell renal cell carcinoma (ccRCC) cell lines, and functional experiments delineated that LINC01094 knockdown led to inhibition on ccRCC cell growth and metastasis. Moreover, LINC01094 was activated by FOXM1 at the transcriptional level.
      Title: FOXM1-Activated LINC01094 Promotes Clear Cell Renal Cell Carcinoma Development via MicroRNA 224-5p/CHSY1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • chronic thromboembolic pulmonary hypertension RNA
    • lincRNA-ANXA3
    • lncRNA CTEPH-associated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038303.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC112253, AK130099, BC040182, DA199752

    2. NR_038304.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1.
      Source sequence(s)
      AC112253, AK124062, BC040182, DA199752

    3. NR_038305.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1.
      Source sequence(s)
      AC112253, BC040182, DA199752

    4. NR_038306.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons, compared to variant 1.
      Source sequence(s)
      AC112253, AK057213, BC040182, DA199752

    5. NR_038307.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons, compared to variant 1.
      Source sequence(s)
      AC112253, BC040182, CB155346, DA199752

    6. NR_038308.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two internal exons and uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      AC112253, BC040182, DA199752

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      78645994..78684501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      81981571..82020092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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