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    Tmprss4 transmembrane serine protease 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmprss4provided by RGD
    Official Full Name
    transmembrane serine protease 4provided by RGD
    Primary source
    RGD:1305033
    See related
    EnsemblRapid:ENSRNOG00000026650 AllianceGenome:RGD:1305033
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type peptidase activity. Predicted to be involved in protein processing. Predicted to act upstream of or within negative regulation of growth rate; regulation of gene expression; and response to wounding. Predicted to be located in extracellular space and secretory granule. Orthologous to human TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 23.9), Uterus (RPKM 17.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmprss4 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54372805..54405157, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45475819..45508409, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49469804..49503304, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel beta subunit 2 Neighboring gene sodium voltage-gated channel beta subunit 4 Neighboring gene small integral membrane protein 35 Neighboring gene uncharacterized LOC120094136 Neighboring gene interleukin 10 receptor subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes. Zang R, et al. Sci Immunol, 2020 May 13. PMID 32404436, Free PMC Article
    2. Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury. Valero-Jiménez A, et al. PLoS One, 2018. PMID 29529050, Free PMC Article
    3. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of growth rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 4
    Names
    transmembrane protease, serine 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108998.1 → NP_001102468.1  transmembrane protease serine 4

      See identical proteins and their annotated locations for NP_001102468.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A6J433, D3Z9X4
      Related
      ENSRNOP00000046830.3, ENSRNOT00000040313.6
      Conserved Domains (5) summary
      smart00020
      Location:202 → 427
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:56 → 90
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:203 → 430
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:118 → 191
      SRCR; Scavenger receptor cysteine-rich domain
      cl02509
      Location:106 → 195
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      54372805..54405157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081860.2 → XP_038937788.1  transmembrane protease serine 4 isoform X1

      Conserved Domains (3) summary
      smart00020
      Location:245 → 470
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:99 → 133
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl02509
      Location:149 → 238
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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