Slc17a8 solute carrier family 17 member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc17a8provided by RGD
Official Full Name: solute carrier family 17 member 8provided by RGD
Primary source: RGD:628870
See related: EnsemblRapid:ENSRNOG00000007581 AllianceGenome:RGD:628870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vglut3
Summary: Enables L-glutamate uniporter activity and chloride channel activity. Involved in several processes, including L-glutamate transmembrane transport; cochlea development; and regulation of acetylcholine uptake. Located in several cellular components, including axon; cytoplasmic vesicle; and dendrite. Biomarker of Parkinsonism; cochlear disease; sciatic neuropathy; transient cerebral ischemia; and trichinosis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 7.5), Liver (RPKM 3.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (25881557..25936837, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (23994212..24049498, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (30215231..30274993, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study.
Title: DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study.
Chronic voluntary wheel running results in increased gene expression of VGLUT3 (and GLT-1) in the frontal cortex without changes in other glutamate transporter subtypes.
Title: Increased gene expression of selected vesicular and glial glutamate transporters in the frontal cortex in rats exposed to voluntary wheel running.
VGLUT3 is involved in the pathogenesis of visceral hyperalgesia in a rat model of irritable bowel syndrome.
Title: Increased VGLUT3 involved in visceral hyperalgesia in a rat model of irritable bowel syndrome.
contribution of distinct VGLUT3 and VMAT2 transporter expression induced by BDNF might be one of the mechanisms that BDNF regulates neuropathic pain
Title: The expression of vesicular glutamate transporter 3 and vesicular monoamine transporter 2 induced by brain-derived neurotrophic factor in dorsal root ganglion neurons in vitro.
VGLUT3 likely has developmental and physiological roles in the rat cochlea during postnatal development as well as later in life
Title: Temporospatial expression and cellular localization of VGLUT3 in the rat cochlea.
The results of this study rat brains showing that small, clear, and round synaptic vesicles in gamma-aminobutyric acid (GABA)-ergic nerve terminals contain labeling for both VGLUT3 and the vesicular GABA transporter .
Title: Vesicular glutamate transporter-3 in the rodent brain: vesicular colocalization with vesicular γ-aminobutyric acid transporter.
Natural rewards and pain have distinct effects on the VGLUT expression pattern in the nucleus accumbens.
Title: Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens.
VGLUT3-immunoreactive boutons in the lateral sinus form two different, disproportionate, populations of synaptic contacts with their target neurons.
Title: VGLUT3-immunoreactive afferents of the lateral septum: ultrastructural evidence for a modulatory role of glutamate.
VGLUT3 localizes to a distinct set of synaptic-like microvesicles in perisynaptic astroglial processes and may be important for glutamate release from astrocytes.
Title: A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3.
The periodontal Ruffini endings of rat incisors show both VGluT1 and VGluT2, and lack VGluT3.
Title: Vesicular glutamate transporter immunoreactivity in the periodontal ligament of the rat incisor.

Submit: New GeneRIF Correction See all GeneRIFs (33)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate uniporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate uniporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamate uniporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-glutamate import	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-glutamate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neural retina development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter loading into synaptic vesicle	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glutamate uptake involved in transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate uptake involved in transmission of nerve impulse	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of acetylcholine uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of acetylcholine uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structure or activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in basal dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in excitatory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glial limiting end-foot	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in pericellular basket	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicular glutamate transporter 3

Names: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; solute carrier family 17 (vesicular glutamate transporter), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153725.2 → NP_714947.1 vesicular glutamate transporter 3

See identical proteins and their annotated locations for NP_714947.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q7TSF2, Q8K1Q1

UniProtKB/TrEMBL

A6IFR4

Related

ENSRNOP00000075876.1, ENSRNOT00000092527.3

Conserved Domains (1) summary

cd17382
Location:79 → 502

MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

25881557..25936837 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078509.2 → XP_038934437.1 vesicular glutamate transporter 3 isoform X1

Related

ENSRNOP00000102402.1, ENSRNOT00000146419.1

Conserved Domains (1) summary

cd17382
Location:79 → 452

MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters