Zfyve26 zinc finger FYVE-type containing 26 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfyve26provided by RGD
Official Full Name: zinc finger FYVE-type containing 26provided by RGD
Primary source: RGD:1307820
See related: EnsemblRapid:ENSRNOG00000059875 AllianceGenome:RGD:1307820
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein kinase binding activity. Predicted to be involved in double-strand break repair via homologous recombination and regulation of cytokinesis. Predicted to act upstream of or within autophagosome organization and lysosome organization. Predicted to be located in early endosome; late endosome; and lysosome. Predicted to be active in centrosome and midbody. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 61.5), Spleen (RPKM 60.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (103764864..103828520, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (98031874..98095538, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (102409235..102472962, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH130880 (e-PCR)
- UniSTS:214164

BF406060 (e-PCR)
- UniSTS:248267

RH135341 (e-PCR)
- UniSTS:218618

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagosome organization	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger FYVE domain-containing protein 26

Names: zinc finger, FYVE domain containing 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108038.1 → NP_001101508.1 zinc finger FYVE domain-containing protein 26

See identical proteins and their annotated locations for NP_001101508.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/Swiss-Prot

D3ZB97, D3ZBA4, D4A8G9

UniProtKB/TrEMBL

A0A8I5ZLS5

Related

ENSRNOP00000078943.1, ENSRNOT00000107207.2

Conserved Domains (1) summary

cd15724
Location:1812 → 1872

FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

103764864..103828520 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261931.1 → XP_063118001.1 zinc finger FYVE domain-containing protein 26 isoform X3

UniProtKB/TrEMBL

A0A8I5ZLS5
XM_039112292.2 → XP_038968220.1 zinc finger FYVE domain-containing protein 26 isoform X2

UniProtKB/TrEMBL

A0A8I5ZLS5

Conserved Domains (1) summary

cd15724
Location:1813 → 1873

FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)
XM_039112291.2 → XP_038968219.1 zinc finger FYVE domain-containing protein 26 isoform X1

UniProtKB/TrEMBL

A0A0G2K770, A0A8I5ZLS5

Related

ENSRNOP00000074087.2, ENSRNOT00000079351.3

Conserved Domains (1) summary

cd15724
Location:1814 → 1874

FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)